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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1991-11-22
|
| pubmed:abstractText |
We report a retrospective review of 223 patients who presented to the Department of Head and Neck Surgery from 1970 through 1987 with a diagnosis of metastatic adenocarcinoma of unknown primary origin. Multivariate analysis was performed using the following parameters: age, sex, initial side and site of nodal involvement, involvement of other body sites, degree of differentiation, treatment modality, outcome, and survival. Follow-up was obtained in all patients, with a minimum of 2 years for survivors. Average age was 55 years, with an approximately equal male:female ratio. The most common site of presentation was the supraclavicular fossa (76%). The initial side of presentation was the left neck in 53% of patients, right neck in 33%, and bilateral in 14%. Metastatic disease to other body sites was present in 86% of patients, with the most common sites being mediastinum (35%), lung (21%), and bones (19%). Increased survival was associated with unilateral neck involvement (p = 0.001) and disease limited to nodes above the cricoid cartilage (p = 0.007). Mean survival was 17 months, with a median of 8 months. Death was due to the index cancer in all but four patients; three of these four patients died of treatment-related causes. Survival was 20% at 2 years and 9% at 5 years. Length of survival was not affected by age, sex, initial side of neck disease, location of other metastatic sites, histologic appearance, or treatment modality. Our current algorithm for the work-up and treatment of this lethal disease is explained.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0002-9610
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
162
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
306-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1951879-Adenocarcinoma,
pubmed-meshheading:1951879-Algorithms,
pubmed-meshheading:1951879-Female,
pubmed-meshheading:1951879-Head and Neck Neoplasms,
pubmed-meshheading:1951879-Humans,
pubmed-meshheading:1951879-Lymphatic Metastasis,
pubmed-meshheading:1951879-Male,
pubmed-meshheading:1951879-Middle Aged,
pubmed-meshheading:1951879-Multivariate Analysis,
pubmed-meshheading:1951879-Neoplasms, Unknown Primary,
pubmed-meshheading:1951879-Retrospective Studies,
pubmed-meshheading:1951879-Survival Analysis,
pubmed-meshheading:1951879-Survival Rate
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Metastatic adenocarcinoma to the neck from an unknown primary source.
|
| pubmed:affiliation |
Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston.
|
| pubmed:publicationType |
Journal Article
|