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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-14
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pubmed:abstractText |
mTOR signaling has been suggested to be an important factor involved in tumorigenesis, but its role in human colorectal cancer (CRC) has not been completely elucidated. Herein, the purpose of this study was to analyze the distribution pattern of mTOR signaling components in CRC and adenoma and to determine whether targeted inhibition of mTOR could be a potential therapeutic strategy for CRC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/EIF4EBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 70-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/mTOR protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1534-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2617-28
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19517193-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19517193-Adenoma,
pubmed-meshheading:19517193-Adult,
pubmed-meshheading:19517193-Aged,
pubmed-meshheading:19517193-Aged, 80 and over,
pubmed-meshheading:19517193-Animals,
pubmed-meshheading:19517193-Apoptosis,
pubmed-meshheading:19517193-Cell Cycle,
pubmed-meshheading:19517193-Cell Proliferation,
pubmed-meshheading:19517193-Colon,
pubmed-meshheading:19517193-Colorectal Neoplasms,
pubmed-meshheading:19517193-Female,
pubmed-meshheading:19517193-Humans,
pubmed-meshheading:19517193-Lymphatic Metastasis,
pubmed-meshheading:19517193-Male,
pubmed-meshheading:19517193-Mice,
pubmed-meshheading:19517193-Mice, Inbred BALB C,
pubmed-meshheading:19517193-Mice, Nude,
pubmed-meshheading:19517193-Middle Aged,
pubmed-meshheading:19517193-Phosphoproteins,
pubmed-meshheading:19517193-Protein Kinases,
pubmed-meshheading:19517193-RNA, Small Interfering,
pubmed-meshheading:19517193-Rectum,
pubmed-meshheading:19517193-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:19517193-Signal Transduction,
pubmed-meshheading:19517193-TOR Serine-Threonine Kinases,
pubmed-meshheading:19517193-Tumor Cells, Cultured
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pubmed:year |
2009
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pubmed:articleTitle |
mTOR signaling pathway is a target for the treatment of colorectal cancer.
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pubmed:affiliation |
Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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