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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-6-11
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pubmed:abstractText |
The variable number tandem repeat (VNTR) polymorphism 5-repeat allele of the circadian gene PERIOD3 (PER3(5/5)) has been associated with cognitive decline at a specific circadian phase in response to a night of total sleep deprivation (TSD), relative to the 4-repeat allele (PER3(4/4)). PER3(5/5) has also been related to higher sleep homeostasis, which is thought to underlie this cognitive vulnerability. To date, no study has used a candidate gene approach to investigate the response to chronic partial sleep deprivation (PSD), a condition distinct from TSD and one commonly experienced by millions of people on a daily and persistent basis. We evaluated whether the PER3 VNTR polymorphism contributed to cumulative neurobehavioral deficits and sleep homeostatic responses during PSD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516903-11306557,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e5874
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pubmed:dateRevised |
2011-2-14
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pubmed:meshHeading |
pubmed-meshheading:19516903-Adult,
pubmed-meshheading:19516903-Alleles,
pubmed-meshheading:19516903-Cognition,
pubmed-meshheading:19516903-Female,
pubmed-meshheading:19516903-Homeostasis,
pubmed-meshheading:19516903-Humans,
pubmed-meshheading:19516903-Male,
pubmed-meshheading:19516903-Middle Aged,
pubmed-meshheading:19516903-Minisatellite Repeats,
pubmed-meshheading:19516903-Models, Neurological,
pubmed-meshheading:19516903-Polymorphism, Genetic,
pubmed-meshheading:19516903-Sleep,
pubmed-meshheading:19516903-Sleep Deprivation,
pubmed-meshheading:19516903-Sleep Stages,
pubmed-meshheading:19516903-Wakefulness
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pubmed:year |
2009
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pubmed:articleTitle |
PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.
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pubmed:affiliation |
Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. goel@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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