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rdf:type |
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lifeskim:mentions |
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0021081,
umls-concept:C0079405,
umls-concept:C0205171,
umls-concept:C0205250,
umls-concept:C0208973,
umls-concept:C0871161,
umls-concept:C1517892,
umls-concept:C1704666,
umls-concept:C1709915
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pubmed:issue |
6
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pubmed:dateCreated |
2009-6-11
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pubmed:abstractText |
A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence factor. We hypothesize that Vpr protein packaged in the virion may be required for disabling APCs of the first infected mucosal tissues. Consistent with this idea are reports that defects in the C-terminus of Vpr are associated with long-term non-progression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-10910069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-11000245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-11017102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-11044109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-11177395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-11509618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12367754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12390540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12396610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12444143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12724343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12750393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12750404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12823956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-12928369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-15053338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-15571493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-15611322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-15956545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-16022656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-16131313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-16470121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18157016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18231576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18434400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18638397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18779746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18832685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-18928538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-7769682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-7903123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-7908324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-8096699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-8806556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-9192902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19516896-9925788
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e5853
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19516896-Dendritic Cells,
pubmed-meshheading:19516896-Gene Products, vpr,
pubmed-meshheading:19516896-HIV Infections,
pubmed-meshheading:19516896-Humans,
pubmed-meshheading:19516896-Immunosuppressive Agents,
pubmed-meshheading:19516896-Interleukin-12,
pubmed-meshheading:19516896-Mucous Membrane,
pubmed-meshheading:19516896-Mutation,
pubmed-meshheading:19516896-Plasmids,
pubmed-meshheading:19516896-Protein Structure, Tertiary,
pubmed-meshheading:19516896-RNA, Viral,
pubmed-meshheading:19516896-Transcription, Genetic,
pubmed-meshheading:19516896-Ubiquitin,
pubmed-meshheading:19516896-Virulence Factors,
pubmed-meshheading:19516896-vpr Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2009
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pubmed:articleTitle |
The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.
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pubmed:affiliation |
Research and Development Department, Argos Therapeutics Inc, Durham, NC, USA. itcherepanova@argostherapeutics.com
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pubmed:publicationType |
Journal Article
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