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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-9-28
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pubmed:abstractText |
Nanotechnology is an important and emerging industry with a projected annual market of around one trillion US dollars by 2011-2015. Concerns about the toxicity of nanomaterials in humans, however, have recently been raised. Although studies of nanoparticle toxicity have focused on lung disease the molecular link between nanoparticle exposure and lung injury remained unclear. In this report, we show that cationic Starburst polyamidoamine dendrimer (PAMAM), a class of nanomaterials that are being widely developed for clinical applications can induce acute lung injury in vivo. PAMAM triggers autophagic cell death by deregulating the Akt-TSC2-mTOR signaling pathway. The autophagy inhibitor 3-methyladenine rescued PAMAM dendrimer-induced cell death and ameliorated acute lung injury caused by PAMAM in mice. Our data provide a molecular explanation for nanoparticle-induced lung injury, and suggest potential remedies to address the growing concerns of nanotechnology safety.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dendrimers,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PAMAM Starburst,
http://linkedlifedata.com/resource/pubmed/chemical/Polyamines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/mTOR protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/tuberous sclerosis complex 2 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1759-4685
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pubmed:author |
pubmed-author:ChenXipingX,
pubmed-author:DengJiejieJ,
pubmed-author:GuoChenyingC,
pubmed-author:GuoFengF,
pubmed-author:HanJ-HJH,
pubmed-author:JiangChengyuC,
pubmed-author:LiChenggangC,
pubmed-author:LiDangshengD,
pubmed-author:LiLiminL,
pubmed-author:LiuHaolinH,
pubmed-author:MiaoYufaY,
pubmed-author:OttóSS,
pubmed-author:RaoShuanS,
pubmed-author:WangHengH,
pubmed-author:WangHongliangH,
pubmed-author:XuHaiyanH,
pubmed-author:YangSunS,
pubmed-author:ZhangYanliY
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pubmed:issnType |
Electronic
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-45
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19516051-Acute Lung Injury,
pubmed-meshheading:19516051-Animals,
pubmed-meshheading:19516051-Autophagy,
pubmed-meshheading:19516051-Cell Line, Tumor,
pubmed-meshheading:19516051-Dendrimers,
pubmed-meshheading:19516051-Humans,
pubmed-meshheading:19516051-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:19516051-Mice,
pubmed-meshheading:19516051-Nanoparticles,
pubmed-meshheading:19516051-Polyamines,
pubmed-meshheading:19516051-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19516051-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19516051-Signal Transduction,
pubmed-meshheading:19516051-Survival Analysis,
pubmed-meshheading:19516051-TOR Serine-Threonine Kinases,
pubmed-meshheading:19516051-Tumor Suppressor Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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