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rdf:type |
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lifeskim:mentions |
umls-concept:C0009938,
umls-concept:C0021368,
umls-concept:C0024109,
umls-concept:C0026336,
umls-concept:C0031164,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0175677,
umls-concept:C0439793,
umls-concept:C0442805,
umls-concept:C0848483
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-27
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pubmed:abstractText |
Lung contusion (LC) from blunt thoracic trauma is a clinically-prevalent condition that can progress to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Patients with LC are at risk for gastric aspiration at the time of trauma, but the combined insults have not been well-studied in animal models. This study tests the hypothesis that concurrent gastric aspiration (combined acid and small gastric particles, CASP) at the time of trauma significantly increases permeability injury and inflammation compared with LC alone, and also modifies the inflammatory response to include distinct features compared with the aspiration component of injury.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-10443613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-10893199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-10921576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-11228282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-11493778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-14758144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-15371091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-15757954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-15778247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-16044083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-16244015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-16394693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-2920593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-3001018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-389910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-7064067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-7509706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-8214660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19515386-9191684
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-82
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pubmed:dateRevised |
2011-2-14
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pubmed:meshHeading |
pubmed-meshheading:19515386-Acute Lung Injury,
pubmed-meshheading:19515386-Albumins,
pubmed-meshheading:19515386-Animals,
pubmed-meshheading:19515386-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19515386-Cell Count,
pubmed-meshheading:19515386-Cell Membrane Permeability,
pubmed-meshheading:19515386-Contusions,
pubmed-meshheading:19515386-Cytokines,
pubmed-meshheading:19515386-Lung,
pubmed-meshheading:19515386-Male,
pubmed-meshheading:19515386-Models, Animal,
pubmed-meshheading:19515386-Oxygen,
pubmed-meshheading:19515386-Peroxidase,
pubmed-meshheading:19515386-Pneumonia,
pubmed-meshheading:19515386-Rats,
pubmed-meshheading:19515386-Rats, Long-Evans,
pubmed-meshheading:19515386-Respiratory Aspiration,
pubmed-meshheading:19515386-Respiratory Mechanics,
pubmed-meshheading:19515386-Severity of Illness Index
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pubmed:year |
2009
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pubmed:articleTitle |
Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion.
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pubmed:affiliation |
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA. kraghave@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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