Linked Life Data

19514649

Source:http://linkedlifedata.com/resource/pubmed/id/19514649

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-6-11
pubmed:abstractText
Acanthosis nigricans (AN) is a skin disorder characterized by focal or diffuse hyperkeratosis symmetric hyperpigmentation of the skin and oral cavity mucosa. Various neoplasms, especially gastrointestinal adenocarcinomas are associated with acanthosis nigricans (AN malignant). Chemotherapy may cause regression of skin lesions. The etiology of AN is not clear. A role of growth factors such as melanocyte stimulating hormone alpha, transforming growth factor alpha, and insulin-like growth factor 1 has been discussed. Two cases of AN have been reported in this paper. Both have been associated with gastric adenocarcinoma. In the first case skin lesions were sensitive to chemotherapy (until cancer progression), while in the second case treatment had to be discontinued because of cardiotoxity without regression of skin lesions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0032-3772
pubmed:author
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
180-3
pubmed:dateRevised
2010-4-1
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature.
pubmed:affiliation
Department of Internal Diseases and Oncological Chemotherapy, Medical University of Silesia, Katowice, Poland. mirella.krawczyk@wp.pl
pubmed:publicationType
Journal Article, Review, Case Reports