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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-6-26
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pubmed:abstractText |
Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establishment of the QX-314-mediated block would limit clinical utility. Because TRPV1 channels are also activated by lidocaine, the authors tested whether lidocaine can substitute for capsaicin to introduce QX-314 into nociceptors through TRPV1 channels and produce selective analgesia.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-10440374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-10694225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-10764638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-12459673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-12654248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-15981012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-16110328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-1612959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-16174788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-16306739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-17167076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-17667576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-17914397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-18032651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-18172555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-18574153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-18689441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-1879174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-1919666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-19512864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-2546451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-2780068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-3340425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-4316945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-4541340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-5150675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-5410937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-728531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-7717536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-7990513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-8091041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-8524860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-8630132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-8783074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19512868-9535944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-1175
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pubmed:author |
pubmed-author:BeanBruce PBP,
pubmed-author:BinshtokAlexander MAM,
pubmed-author:ChungGehoonG,
pubmed-author:GernerPeterP,
pubmed-author:HerbertTeriT,
pubmed-author:KimDonghoonD,
pubmed-author:MitaniAya AAA,
pubmed-author:OhSeog BaeSB,
pubmed-author:PuopoloMichelinoM,
pubmed-author:RobersonDavid PDP,
pubmed-author:ValentiniValentinoV,
pubmed-author:WangChi-FeiCF,
pubmed-author:WangGing KuoGK,
pubmed-author:WoolfClifford JCJ
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pubmed:issnType |
Electronic
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-37
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19512868-Animals,
pubmed-meshheading:19512868-Cells, Cultured,
pubmed-meshheading:19512868-Drug Therapy, Combination,
pubmed-meshheading:19512868-Lidocaine,
pubmed-meshheading:19512868-Male,
pubmed-meshheading:19512868-Mice,
pubmed-meshheading:19512868-Mice, Inbred C57BL,
pubmed-meshheading:19512868-Mice, Knockout,
pubmed-meshheading:19512868-Pain Measurement,
pubmed-meshheading:19512868-Rats,
pubmed-meshheading:19512868-Rats, Sprague-Dawley,
pubmed-meshheading:19512868-Sodium Channel Blockers,
pubmed-meshheading:19512868-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.
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pubmed:affiliation |
Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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