Source:http://linkedlifedata.com/resource/pubmed/id/19507501
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
2009-6-10
|
pubmed:abstractText |
A variety of genomic approaches have been applied to leukemia/lymphoma to identify cancer-promoting genes or to screen for prognostic markers. Gene expression profiling with microarrays has, for instance, succeeded to calculate prognostic scores based on the expression profiles of a subset of genes in acute myeloid leukemia and non-Hodgkin lymphoma. Further, narrowing down the LOH regions with microsatellite markers in the genome of myeloproliferative disorders could identify a mutated JAK2 gene encoding an activated tyrosine kinase. Similarly, a common deletion in the genome of chronic lymphoid leukemia was shown to contain miR-15a/miR-16-1 microRNA genes, loss of expression of which plays an important role in the malignant transformation. Advent of further high-throughput and high-resolution techniques (such as new generation of DNA sequencers) would greatly help to discover leukemia/lymphoma-related genes that may provide promising candidates for molecule-targeted therapies.
|
pubmed:language |
jpn
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0047-1852
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
67
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1109-14
|
pubmed:dateRevised |
2011-7-27
|
pubmed:meshHeading |
pubmed-meshheading:19507501-Chromosome Aberrations,
pubmed-meshheading:19507501-Gene Expression Profiling,
pubmed-meshheading:19507501-Humans,
pubmed-meshheading:19507501-Janus Kinase 2,
pubmed-meshheading:19507501-Leukemia,
pubmed-meshheading:19507501-Lymphoma,
pubmed-meshheading:19507501-Proteomics
|
pubmed:year |
2009
|
pubmed:articleTitle |
[Medical genomics of leukemia/lymphoma].
|
pubmed:affiliation |
Functional Genomics, Jichi Medical University.
|
pubmed:publicationType |
Journal Article,
English Abstract
|