Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-6-10
pubmed:abstractText
A variety of genomic approaches have been applied to leukemia/lymphoma to identify cancer-promoting genes or to screen for prognostic markers. Gene expression profiling with microarrays has, for instance, succeeded to calculate prognostic scores based on the expression profiles of a subset of genes in acute myeloid leukemia and non-Hodgkin lymphoma. Further, narrowing down the LOH regions with microsatellite markers in the genome of myeloproliferative disorders could identify a mutated JAK2 gene encoding an activated tyrosine kinase. Similarly, a common deletion in the genome of chronic lymphoid leukemia was shown to contain miR-15a/miR-16-1 microRNA genes, loss of expression of which plays an important role in the malignant transformation. Advent of further high-throughput and high-resolution techniques (such as new generation of DNA sequencers) would greatly help to discover leukemia/lymphoma-related genes that may provide promising candidates for molecule-targeted therapies.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1109-14
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Medical genomics of leukemia/lymphoma].
pubmed:affiliation
Functional Genomics, Jichi Medical University.
pubmed:publicationType
Journal Article, English Abstract