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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2009-6-9
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pubmed:abstractText |
Guidelines and recommendations for the acute and prophylactic treatment of bleeding in von Willebrand disease (VWD) patients with von Willebrand factor (VWF)/factor VIII (FVIII) concentrates should be based on the analysis of the content of VWF/FVIII concentrates and on pharmacokinetic studies in patients with different severity of VWD (type 1, type 2 or type 3). The VW/FVIII concentrates should be assessed using the parameters FVIII:coagulant activity (C), VWF:ristocetin cofactor activity (RCo), VWF:collagen binding and VWF multimeric patterns for the presence of large multimers to determine their predicted efficacy and safety in prospective management studies. As the bleeding tendency is moderate in VWD type 2 and severe in type 3 and because the FVIII:C levels are subnormal in type 2 but very low in type 3 VWD patients, new guidelines using VWF:RCo unit dosing for the acute and prophylactic treatment of bleeding episodes are proposed. Such guidelines should be stratified for the severity of bleeding, the type of surgery (minor or major) and also for the bleeding score in either VWD type 1, 2 or 3.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9662
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-76
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19506363-Bleeding Time,
pubmed-meshheading:19506363-Blood Loss, Surgical,
pubmed-meshheading:19506363-Collagen,
pubmed-meshheading:19506363-Deamino Arginine Vasopressin,
pubmed-meshheading:19506363-Drug Combinations,
pubmed-meshheading:19506363-Drug Therapy, Combination,
pubmed-meshheading:19506363-Factor VIII,
pubmed-meshheading:19506363-Genotype,
pubmed-meshheading:19506363-Humans,
pubmed-meshheading:19506363-Intraoperative Care,
pubmed-meshheading:19506363-Platelet Aggregation,
pubmed-meshheading:19506363-Postoperative Hemorrhage,
pubmed-meshheading:19506363-Practice Guidelines as Topic,
pubmed-meshheading:19506363-Preanesthetic Medication,
pubmed-meshheading:19506363-Prospective Studies,
pubmed-meshheading:19506363-Protein Structure, Quaternary,
pubmed-meshheading:19506363-Ristocetin,
pubmed-meshheading:19506363-von Willebrand Diseases,
pubmed-meshheading:19506363-von Willebrand Factor
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pubmed:year |
2009
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pubmed:articleTitle |
Managing patients with von Willebrand disease type 1, 2 and 3 with desmopressin and von Willebrand factor-factor VIII concentrate in surgical settings.
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pubmed:affiliation |
Hemostasis and Thrombosis Research Center, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium. postbus@goodheartcenter.demon.nl
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pubmed:publicationType |
Journal Article,
Review
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