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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-9-11
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pubmed:abstractText |
In obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development of metabolic syndrome. Suppression of inflammation and ROS production in fat may attenuate the metabolic syndrome. Activation of mineralocorticoid receptor (MR) promotes inflammation in heart, kidney, and vasculature via ROS generation. However, the significance of MR in fat remains elusive. Here we investigated whether MR blockade attenuates obesity-related insulin resistance and improves adipocyte dysfunction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
164-72
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pubmed:meshHeading |
pubmed-meshheading:19505930-3T3-L1 Cells,
pubmed-meshheading:19505930-Adipocytes,
pubmed-meshheading:19505930-Adipose Tissue,
pubmed-meshheading:19505930-Animals,
pubmed-meshheading:19505930-Insulin Resistance,
pubmed-meshheading:19505930-Male,
pubmed-meshheading:19505930-Mice,
pubmed-meshheading:19505930-Mice, Inbred C57BL,
pubmed-meshheading:19505930-Mice, Obese,
pubmed-meshheading:19505930-NADPH Oxidase,
pubmed-meshheading:19505930-Obesity,
pubmed-meshheading:19505930-RNA, Messenger,
pubmed-meshheading:19505930-RNA, Small Interfering,
pubmed-meshheading:19505930-Reactive Oxygen Species,
pubmed-meshheading:19505930-Receptors, Mineralocorticoid,
pubmed-meshheading:19505930-Spironolactone
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pubmed:year |
2009
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pubmed:articleTitle |
Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice.
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pubmed:affiliation |
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2-B5 Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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