Linked Life Data

1950583

Source:http://linkedlifedata.com/resource/pubmed/id/1950583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-12-18
pubmed:abstractText
In isolated guinea pig sinus node and crista terminalis cells, berberine, (Ber) 10 mumol.L-1 shortened the S-C and C-H intervals; increased the membrane responsiveness accompanying in the dose dependent inhibition of action potentials of these cells. The sinus cells were more sensitive to the depressive effect of Ber than crista terminalis cells. Similarly, after iv Ber (10 mg.kg-1), the intervals of A-H and H-V were decreased; whereas AERP and AVNFRP prolonged on His bundle electrogram in anesthetized rabbits. The above results indicate that Ber possessed a positive dromotropic effects on both intra-atrial and atrioventricular conductions, which were independent to increase of Vmax and APA. Thus the actions of Ber might be relevant to its effects on myocardial cell membrane by decreasing impedence and increasing electric coupling. Furthermore, Ber 15 mg.kg-1 iv in rabbits caused a severe myocardial inhibition.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Effects of berberine on conductivity of heart].
pubmed:affiliation
Department of Pharmacology, Tongji Medical University, Hankou, China.
pubmed:publicationType
Journal Article, In Vitro, English Abstract, Research Support, Non-U.S. Gov't