Linked Life Data

19504253

Source:http://linkedlifedata.com/resource/pubmed/id/19504253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-6-8
pubmed:abstractText
Insulin resistance, the impaired ability of insulin to stimulate glucose utilization, is a major characteristic of type 2 diabetes. Insulin sensitivity can be measured using a variety of techniques that are commonly employed in diabetes research and care. Of these, hyperinsulinemic-euglycemic clamp is the gold-standard method to assess insulin sensitivity. The euglycemic clamp is widely used in clinics and laboratories to measure insulin action on glucose utilization in humans and animals for clinical and basic science research. Incorporation of radioactive-labeled glucose during euglycemic clamps makes it possible to measure glucose metabolism in individual organs. In recent years, euglycemic clamps have been actively performed in transgenic animal models of obesity, diabetes, and its complications, and have significantly advanced our understanding on the etiology and pathogenesis of type 2 diabetes. This chapter describes our standardized methods of the euglycemic clamp and associated surgical and biochemical procedures to measure insulin sensitivity in conscious rodents.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1940-6029
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
560
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-38
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Hyperinsulinemic-euglycemic clamp to assess insulin sensitivity in vivo.
pubmed:affiliation
UMass Mouse Phenotyping Center, University of Massachusetts Medical School, 381 Plantation Street, Suite 200 Worcester, MA, USA. jason.kim@psu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural