Linked Life Data

19502103

Source:http://linkedlifedata.com/resource/pubmed/id/19502103

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-9-23
pubmed:abstractText
Matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) are two proteins involved in angiogenesis. In the present study we investigated the association of pretreatment MMP-9 and VEGF serum levels with clinicopathological parameters and outcome in patients with oral squamous cell carcinoma. Pretreatment serum levels of MMP-9 and VEGF were analyzed in 161 patients with use of enzyme-linked immunoassays. Patients with a VEGF serum level higher than the mean serum level (497.04 pg/mL) had a significantly shorter overall survival than those with a serum level lower than median (p<0.0001). Patients with MMP-9 serum levels higher than median (226.7 ng/mL) had significantly shorter overall survival than those with levels lower than median (p=0.01). In addition to cervical lymph node metastasis and tumor stage, pretreatment serum levels of MMP-9 and VEGF were identified as independent prognostic factors in multivariate Cox regression analysis. We conclude pretreatment serum levels of MMP-9 and VEGF are new powerful prognostic markers in patients with oral squamous cell carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1368-8375
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
920-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Presurgical serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in oral squamous cell carcinoma.
pubmed:affiliation
Department of Oral and Maxillofacial, MacKay Memorial Hospital, MacKay Medicine, Nursing and Management College, Taipei 10449, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't