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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-5
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pubmed:abstractText |
Latent adenoviral infection may amplify cigarette smoke-induced lung inflammation and therefore play an important role in the development of chronic obstructive pulmonary disease (COPD). Adenoviruses can evade the human immune response via their 19-kDa protein (19K) which delays the expression of class I human leukocyte antigen (HLA) proteins. The 19K protein shows higher affinity to HLA-B7 and A2 compared with HLA-A1 and A3. The receptor for adenovirus (CXADR) and integrin beta(5) (ITGB5) are host factors which might affect adenovirus infection. Therefore, we investigated the contribution of HLA, CXADR, and ITGB5 genetic variants to the presence of the E1A gene and to level of lung function.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1532-3064
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1672-80
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pubmed:dateRevised |
2011-7-1
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pubmed:meshHeading |
pubmed-meshheading:19502044-Adenovirus Infections, Human,
pubmed-meshheading:19502044-Adult,
pubmed-meshheading:19502044-Aged,
pubmed-meshheading:19502044-Aged, 80 and over,
pubmed-meshheading:19502044-Female,
pubmed-meshheading:19502044-Forced Expiratory Volume,
pubmed-meshheading:19502044-Gene Frequency,
pubmed-meshheading:19502044-Genetic Predisposition to Disease,
pubmed-meshheading:19502044-Genotype,
pubmed-meshheading:19502044-HLA Antigens,
pubmed-meshheading:19502044-Humans,
pubmed-meshheading:19502044-Integrin beta Chains,
pubmed-meshheading:19502044-Male,
pubmed-meshheading:19502044-Middle Aged,
pubmed-meshheading:19502044-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:19502044-Questionnaires,
pubmed-meshheading:19502044-Receptors, Virus,
pubmed-meshheading:19502044-Respiratory Function Tests,
pubmed-meshheading:19502044-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19502044-Risk Factors,
pubmed-meshheading:19502044-Smoking
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pubmed:year |
2009
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pubmed:articleTitle |
Role of genetic susceptibility to latent adenoviral infection and decreased lung function.
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pubmed:affiliation |
The James Hogg iCAPTURE Centre, University of British Columbia, St Paul's Hospital, Vancouver, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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