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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0030685,
umls-concept:C0160390,
umls-concept:C0205263,
umls-concept:C0383327,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1880177,
umls-concept:C1963578,
umls-concept:C2346841
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pubmed:issue |
2
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pubmed:dateCreated |
2009-6-30
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pubmed:abstractText |
After treatment with heat-killed Propionibacterium acnes mice show dense hepatic granuloma formation. Such mice develop liver injury in an interleukin (IL)-18-dependent manner after challenge with a sublethal dose LPS. As previously shown, LPS-stimulated Kupffer cells secrete IL-18 depending on caspase-1 and Toll-like receptor (TLR)-4 but independently of its signal adaptor myeloid differentiation factor 88 (MyD88), suggesting importance of another signal adaptor TIR domain-containing adapter inducing IFN-beta (TRIF). Nalp3 inflammasome reportedly controls caspase-1 activation. Here we investigated the roles of MyD88 and TRIF in P. acnes-induced hepatic granuloma formation and LPS-induced caspase-1 activation for IL-18 release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/CIAS1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/TICAM-1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0168-8278
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pubmed:author |
pubmed-author:AkiraShizuoS,
pubmed-author:FujimotoJiroJ,
pubmed-author:HayashiShuheiS,
pubmed-author:ImamuraMichikoM,
pubmed-author:MitaniKeikoK,
pubmed-author:NakanishiKenjiK,
pubmed-author:TaniguchiShun-IchiroS,
pubmed-author:TschoppJurgJ,
pubmed-author:TsutsuiHirokoH,
pubmed-author:UchiyamaRyosukeR,
pubmed-author:Van RooijenNicoN,
pubmed-author:YamamotoTetsuyaT,
pubmed-author:YasudaKoubunK,
pubmed-author:Yumikura-FutatsugiShizueS
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
333-41
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pubmed:meshHeading |
pubmed-meshheading:19501931-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:19501931-Adenosine Triphosphate,
pubmed-meshheading:19501931-Animals,
pubmed-meshheading:19501931-Carrier Proteins,
pubmed-meshheading:19501931-Caspase 1,
pubmed-meshheading:19501931-Female,
pubmed-meshheading:19501931-Granuloma,
pubmed-meshheading:19501931-Interferon-beta,
pubmed-meshheading:19501931-Interleukin-18,
pubmed-meshheading:19501931-Lipopolysaccharides,
pubmed-meshheading:19501931-Liver,
pubmed-meshheading:19501931-Liver Diseases,
pubmed-meshheading:19501931-Macrophages,
pubmed-meshheading:19501931-Mice,
pubmed-meshheading:19501931-Mice, Inbred C57BL,
pubmed-meshheading:19501931-Mice, Knockout,
pubmed-meshheading:19501931-Myeloid Differentiation Factor 88,
pubmed-meshheading:19501931-Propionibacterium acnes,
pubmed-meshheading:19501931-Signal Transduction,
pubmed-meshheading:19501931-Toll-Like Receptor 4
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pubmed:year |
2009
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pubmed:articleTitle |
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.
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pubmed:affiliation |
Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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