Source:http://linkedlifedata.com/resource/pubmed/id/19501916
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-7-14
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| pubmed:abstractText |
Interleukin (IL-7), which is a regulator of development and homeostatic maintenance of T and B cells, is implicated in the induction of leukocyte-endothelial cell adhesion during inflammatory events. We hypothesized that circulating IL-7 is associated with cytokines and chemokines, vascular inflammatory markers and lipid profiles involved in regulating cell adhesion in post-menopausal women. Serum levels of 8 cytokines and chemokines were simultaneously measured in 200 post-menopausal women using a multiplexed human cytokine assay. C-reactive protein, soluble vascular cell adhesion molecule, soluble intercellular adhesion molecule and soluble E-selectin were measured as inflammatory markers. Serum IL-7 concentration was significantly correlated with serum MCP-1 concentration and the correlation remained after adjustment for age and body mass index (BMI). Serum IL-7 levels also showed significant positive correlations with serum levels of IL-10 and IL-6. In addition, the serum IL-7 concentration showed significant positive correlations with levels of soluble E-selectin and triglyceride after adjustment for age and BMI. We conclude that there is a relationship between circulating IL-7, MCP-1 and soluble E-selectin, and that IL-7 may be involved in regulating inflammatory cell adhesion together with MCP-1 and E-selectin in post-menopausal women.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1872-7603
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
81
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
97-102
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| pubmed:meshHeading |
pubmed-meshheading:19501916-Age Factors,
pubmed-meshheading:19501916-Body Mass Index,
pubmed-meshheading:19501916-C-Reactive Protein,
pubmed-meshheading:19501916-Cell Adhesion,
pubmed-meshheading:19501916-Chemokine CCL2,
pubmed-meshheading:19501916-E-Selectin,
pubmed-meshheading:19501916-Female,
pubmed-meshheading:19501916-Humans,
pubmed-meshheading:19501916-Inflammation,
pubmed-meshheading:19501916-Intercellular Adhesion Molecule-1,
pubmed-meshheading:19501916-Interleukin-10,
pubmed-meshheading:19501916-Interleukin-6,
pubmed-meshheading:19501916-Interleukin-7,
pubmed-meshheading:19501916-Middle Aged,
pubmed-meshheading:19501916-Postmenopause,
pubmed-meshheading:19501916-Triglycerides,
pubmed-meshheading:19501916-Vascular Cell Adhesion Molecule-1,
pubmed-meshheading:19501916-Vascular Diseases
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| pubmed:year |
2009
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| pubmed:articleTitle |
Interleukin-7 is associated with monocyte chemoattractant protein-1 and soluble E-selectin levels in peripheral blood of newly post-menopausal women.
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| pubmed:affiliation |
Department of Obstetrics and Gynecology, Human Development and Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
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| pubmed:publicationType |
Journal Article
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