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rdf:type |
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lifeskim:mentions |
umls-concept:C0012737,
umls-concept:C0019169,
umls-concept:C0035647,
umls-concept:C0037140,
umls-concept:C0086860,
umls-concept:C0205245,
umls-concept:C0205419,
umls-concept:C0330390,
umls-concept:C0524909,
umls-concept:C0597357,
umls-concept:C1415900
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pubmed:issue |
2
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pubmed:dateCreated |
2009-6-30
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pubmed:abstractText |
We previously demonstrated that two linked single nucleotide polymorphisms (SNPs) at -408 and -3 of type I interferon receptor 1 (IFNAR1) promoter are associated with susceptibility to chronic HBV infection. We aimed to elucidate the mechanism by which -3 and/or -408 C/T SNPs had such profound effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/HMGB1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/IFNAR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PARP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Interferon alpha-beta
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0168-8278
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pubmed:author |
pubmed-author:ChanChris C SCC,
pubmed-author:ChenDing-QiangDQ,
pubmed-author:GuanXin-YuanXY,
pubmed-author:HuangJian-DongJD,
pubmed-author:IpH HHH,
pubmed-author:LuLiweiL,
pubmed-author:PoonVincent K MVK,
pubmed-author:WattRory MRM,
pubmed-author:YuenKwok-YungKY,
pubmed-author:ZhengBo-JianBJ,
pubmed-author:ZhouJieJ
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
322-32
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pubmed:meshHeading |
pubmed-meshheading:19501422-Alleles,
pubmed-meshheading:19501422-Base Sequence,
pubmed-meshheading:19501422-Cell Line,
pubmed-meshheading:19501422-DNA,
pubmed-meshheading:19501422-DNA Primers,
pubmed-meshheading:19501422-Down-Regulation,
pubmed-meshheading:19501422-Genetic Predisposition to Disease,
pubmed-meshheading:19501422-HMGB1 Protein,
pubmed-meshheading:19501422-Hepatitis B, Chronic,
pubmed-meshheading:19501422-Humans,
pubmed-meshheading:19501422-Kinetics,
pubmed-meshheading:19501422-Models, Biological,
pubmed-meshheading:19501422-Molecular Sequence Data,
pubmed-meshheading:19501422-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:19501422-Polymorphism, Single Nucleotide,
pubmed-meshheading:19501422-Prognosis,
pubmed-meshheading:19501422-Promoter Regions, Genetic,
pubmed-meshheading:19501422-Protein Binding,
pubmed-meshheading:19501422-RNA, Messenger,
pubmed-meshheading:19501422-Receptor, Interferon alpha-beta,
pubmed-meshheading:19501422-Risk Factors,
pubmed-meshheading:19501422-Transcriptional Activation,
pubmed-meshheading:19501422-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.
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pubmed:affiliation |
Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Pokfulam, Hong Kong.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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