19501000

Source:http://linkedlifedata.com/resource/pubmed/id/19501000

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012634, umls-concept:C0035820, umls-concept:C0599779, umls-concept:C0678209
pubmed:issue	6
pubmed:dateCreated	2009-6-22
pubmed:abstractText	NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response to IL-1-targeted therapy. We developed two Nlrp3 mutant knockin mouse strains to model CAPS to examine the role of other inflammatory mediators and adaptive immune responses in an innate immune-driven disease. These mice had systemic inflammation and poor growth, similar to some human CAPS patients, and demonstrated early mortality, primarily mediated by myeloid cells. Mating these mutant mice to various gene mutant backgrounds showed that the mouse disease phenotype required an intact inflammasome, was only partially dependent on IL-1beta, and was independent of T cells. These data suggest that CAPS are true inflammasome-mediated diseases and provide insight for more common inflammatory disorders.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 AI052430-06, http://linkedlifedata.com/resource/pubmed/grant/R01 AI052430-07, http://linkedlifedata.com/resource/pubmed/grant/R01 AI052430-08, http://linkedlifedata.com/resource/pubmed/grant/R01 AI052430-10, http://linkedlifedata.com/resource/pubmed/grant/R01-AI52430, http://linkedlifedata.com/resource/pubmed/grant/R21 AI061108-01, http://linkedlifedata.com/resource/pubmed/grant/R21 AI061108-02
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-10621974, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-11971877, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-12667444, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-14634131, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-15030775, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-1547488, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-15541451, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-15967716, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-16407888, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-16407889, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-17164409, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-17964261, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-18400188, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-18668535, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-18827826, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-19362022, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-19538926, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-3332485, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-9317135, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-9504047, http://linkedlifedata.com/resource/pubmed/commentcorrection/19501000-9553774
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9432918
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/CIAS1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1097-4180
pubmed:author	pubmed-author:BoyleDavid LDL, pubmed-author:BrydgesSusannah DSD, pubmed-author:FiresteinGary SGS, pubmed-author:GandhiChhaviC, pubmed-author:HoffmanHal MHM, pubmed-author:HornerAnthony AAA, pubmed-author:KastnerDaniel LDL, pubmed-author:McGeoughMatthew DMD, pubmed-author:MisaghiAmirhosseinA, pubmed-author:MuellerJames LJL, pubmed-author:O'SheaJohn JJJ, pubmed-author:PenaCarla ACA, pubmed-author:PutnamChris DCD, pubmed-author:SorooshPejmanP, pubmed-author:WatfordWendy TWT
pubmed:issnType	Electronic
pubmed:day	19
pubmed:volume	30
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	875-87
pubmed:dateRevised	2011-6-1
pubmed:meshHeading	pubmed-meshheading:19501000-Animals, pubmed-meshheading:19501000-B-Lymphocytes, pubmed-meshheading:19501000-Carrier Proteins, pubmed-meshheading:19501000-Cytokines, pubmed-meshheading:19501000-Disease Models, Animal, pubmed-meshheading:19501000-Gene Knock-In Techniques, pubmed-meshheading:19501000-Immunity, Active, pubmed-meshheading:19501000-Immunity, Innate, pubmed-meshheading:19501000-Inflammation, pubmed-meshheading:19501000-Interleukin-18, pubmed-meshheading:19501000-Interleukin-1beta, pubmed-meshheading:19501000-Mice, pubmed-meshheading:19501000-Mice, Mutant Strains, pubmed-meshheading:19501000-Mutation, pubmed-meshheading:19501000-T-Lymphocytes
pubmed:year	2009
pubmed:articleTitle	Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
pubmed:affiliation	Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural