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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
33
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pubmed:dateCreated |
2009-7-3
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pubmed:abstractText |
Serogroup C meningococcal conjugate vaccines were introduced in Greece in 2001, and although no cases of serogroup C meningococcal disease were recorded in 2004, a steady increase was observed since 2005. In this study, serum bactericidal activity was assessed in sera of 269 vaccinated children at a mean time of about 5 years after vaccination. Non-protective antibody titers were observed in most children vaccinated at age <6 years (85.9%), followed by those between 6 and 10 years (62.2%). This percentage was considerably lower in adolescents vaccinated at an age >10 years (37.8%) (p<0.01). Geometric mean concentrations of serum IgG antibodies against serogroup C showed a similar variation. The results indicate that serum bactericidal antibody titers significantly correlate with age of vaccination; most children do not have protective antibody titers few years after immunization in infancy and childhood whereas most adolescents maintain sustained protection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1873-2518
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pubmed:author |
pubmed-author:BarbouniAnastasiaA,
pubmed-author:BlackwellCaroline CCC,
pubmed-author:KafetzisDimitrisD,
pubmed-author:KremastinouJennyJ,
pubmed-author:KyprianouMiltiadesM,
pubmed-author:PapaevangelouVanaV,
pubmed-author:SakouIrine-IkbaleII,
pubmed-author:SioumalaMariaM,
pubmed-author:TsitsikaArtemisA,
pubmed-author:TsoliaMaria NMN,
pubmed-author:TzanakakiGeorginaG
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
27
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
4408-11
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pubmed:dateRevised |
2009-8-20
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pubmed:meshHeading |
pubmed-meshheading:19500554-Adolescent,
pubmed-meshheading:19500554-Age Factors,
pubmed-meshheading:19500554-Antibodies, Bacterial,
pubmed-meshheading:19500554-Blood Bactericidal Activity,
pubmed-meshheading:19500554-Child,
pubmed-meshheading:19500554-Child, Preschool,
pubmed-meshheading:19500554-Cross-Sectional Studies,
pubmed-meshheading:19500554-Greece,
pubmed-meshheading:19500554-Humans,
pubmed-meshheading:19500554-Immunoglobulin G,
pubmed-meshheading:19500554-Meningitis, Meningococcal,
pubmed-meshheading:19500554-Meningococcal Vaccines,
pubmed-meshheading:19500554-Neisseria meningitidis, Serogroup C,
pubmed-meshheading:19500554-Time Factors,
pubmed-meshheading:19500554-Vaccines, Conjugate
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pubmed:year |
2009
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pubmed:articleTitle |
Investigation of serum bactericidal activity in childhood and adolescence 3-6 years after vaccination with a single dose of serogroup C meningococcal conjugate vaccine.
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pubmed:affiliation |
National Meningitis Reference Laboratory, National School of Public Health, 196, Alexandras Avenue, Athens, Greece.
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pubmed:publicationType |
Journal Article
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