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rdf:type |
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lifeskim:mentions |
umls-concept:C0033684,
umls-concept:C0037083,
umls-concept:C0038435,
umls-concept:C0205099,
umls-concept:C0309311,
umls-concept:C0439784,
umls-concept:C0871261,
umls-concept:C1418656,
umls-concept:C1424870,
umls-concept:C1442080,
umls-concept:C1704632,
umls-concept:C1706057,
umls-concept:C1706817,
umls-concept:C1708726,
umls-concept:C1709059,
umls-concept:C1710082,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2009-10-2
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pubmed:abstractText |
Shortly after the release of singlet oxygen ((1)O(2)) in chloroplasts, changes in nuclear gene expression occur in the conditional flu mutant of Arabidopsis that reveal a rapid transfer of signals from the plastid to the nucleus. Extensive genetic screens aimed at identifying constituents involved in (1)O(2)-mediated plastid-to-nucleus signaling have failed to identify extraplastidic signaling components. This finding suggests that (1)O(2)-mediated signals are not translocated to the nucleus via a single linear pathway, but rather through a signaling network that is difficult to block by single mutations. The complexity of this signaling network has been tackled by mutagenizing a transgenic flu line expressing the luciferase reporter gene under the control of the promoter of a (1)O(2)-responsive AAA-ATPase gene (At3g28580) and isolating second site mutants that constitutively express the reporter gene at a high level. One of the mutants was shown by map-based cloning and sequencing to contain a single amino acid change in the PLEIOTROPIC RESPONSE LOCUS 1 (PRL1) protein. PRL1 suppresses the expression of AAA-ATPase and other (1)O(2)-responsive genes. PRL1 seems to play a major role in modulating responses of plants to environmental changes by interconnecting (1)O(2)-mediated retrograde signaling with other signaling pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1365-313X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-32
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pubmed:meshHeading |
pubmed-meshheading:19500298-Arabidopsis,
pubmed-meshheading:19500298-Arabidopsis Proteins,
pubmed-meshheading:19500298-Carrier Proteins,
pubmed-meshheading:19500298-Cloning, Molecular,
pubmed-meshheading:19500298-Gene Expression Regulation, Plant,
pubmed-meshheading:19500298-Genetic Complementation Test,
pubmed-meshheading:19500298-Mutagenesis,
pubmed-meshheading:19500298-Nuclear Proteins,
pubmed-meshheading:19500298-Photosystem II Protein Complex,
pubmed-meshheading:19500298-Plants, Genetically Modified,
pubmed-meshheading:19500298-RNA, Plant,
pubmed-meshheading:19500298-Signal Transduction,
pubmed-meshheading:19500298-Singlet Oxygen,
pubmed-meshheading:19500298-Stress, Physiological
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pubmed:year |
2009
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pubmed:articleTitle |
Modulation of O-mediated retrograde signaling by the PLEIOTROPIC RESPONSE LOCUS 1 (PRL1) protein, a central integrator of stress and energy signaling.
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pubmed:affiliation |
Institute of Plant Sciences, ETH Zurich, Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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