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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1991-12-20
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pubmed:abstractText |
1. The imidazole antifungal agent, prochloraz, elicited type II spectral interactions with microsomal cytochromes P-450 from rats pretreated with phenobarbital (PB), 3-methyl-cholanthrene (MC) and dexamethasone (DEX). 2. Prochloraz interacts strongly with type I binding sites of both PB- and DEX-induced cytochromes P-450 and to a lesser extent with cytochromes P-450 from MC-induced rats. 3. The antifungal derivative was a more potent inhibitor of the troleandomycin-nitrosoalkyl-cytochrome P-450 complex formation in DEX-induced microsomes than of the isosafrole-carbene-cytochrome P-450 complex formation in MC-pretreated rats. 4. Prochloraz is a strong inhibitor of the cytochrome P-450-dependent mixed-function oxidases in rat liver microsomal preparations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0049-8254
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
669-78
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1949900-Animals,
pubmed-meshheading:1949900-Cytochrome P-450 Enzyme System,
pubmed-meshheading:1949900-Dexamethasone,
pubmed-meshheading:1949900-Fungicides, Industrial,
pubmed-meshheading:1949900-Imidazoles,
pubmed-meshheading:1949900-Isoenzymes,
pubmed-meshheading:1949900-Male,
pubmed-meshheading:1949900-Methylcholanthrene,
pubmed-meshheading:1949900-Microsomes, Liver,
pubmed-meshheading:1949900-Phenobarbital,
pubmed-meshheading:1949900-Rats,
pubmed-meshheading:1949900-Rats, Inbred Strains
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pubmed:year |
1991
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pubmed:articleTitle |
In vitro effects of an imidazole antifungal, prochloraz, on spectral and catalytic properties of microsomal cytochromes P-450.
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pubmed:affiliation |
Laboratory of Food Toxicology, University of Bordeaux I, Talence, France.
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pubmed:publicationType |
Journal Article
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