Linked Life Data

19497276

Source:http://linkedlifedata.com/resource/pubmed/id/19497276

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
pubmed:issue
6
pubmed:dateCreated
2009-6-5
pubmed:abstractText
Germ cells undergo comprehensive epigenetic reprogramming toward acquiring fitness for pluripotency and totipotency. Notably, the full extent of the epigenetic reprogramming experienced by germ cells remains unmatched by attempts to experimentally restore pluripotency in somatic cells. We propose that the defects present in experimentally generated cells are corrected upon differentiation into the germ cell lineage, as has been observed in cases of germline transmission. Unraveling the mechanisms responsible for germ cell-specific epigenetic reprogramming will likely have important implications for both basic and clinical stem cell research.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1875-9777
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Resetting the epigenome beyond pluripotency in the germline.
pubmed:affiliation
Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't