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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-5
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pubmed:abstractText |
Recurrent focal segmental glomerulosclerosis (FSGS) after renal transplantation with nephrotic syndrome is a serious problem with a high risk of graft loss. The therapeutic role of renin-angiotensin-system (RAS) blockers in recurrent FSGS is not clear. We present the safety and efficacy of an intensified triple RAS blockade with an ACE-inhibitor, an AT 1 receptor blocker and the direct renin inhibitor aliskiren in a 29-year-old renal transplant recipient with biopsy proven recurrence of FSGS and relapsing severe nephrotic syndrome. We subsequently used full dose ramipril, candesartan and aliskiren under a close monitoring of kidney function and electrolytes and examined the effect on proteinuria, clinical course and tolerability over 12 months. We found a significant and sustained antiproteinuric effect under triple RAS blockade. RAS blockade was generally well tolerated. This can offer a new therapeutic approach in selected hypertensive patients with recurrent FSGS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Fumarates,
http://linkedlifedata.com/resource/pubmed/chemical/Ramipril,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/aliskiren,
http://linkedlifedata.com/resource/pubmed/chemical/candesartan,
http://linkedlifedata.com/resource/pubmed/chemical/rituximab
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1432-2277
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1110-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19497068-Adult,
pubmed-meshheading:19497068-Amides,
pubmed-meshheading:19497068-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:19497068-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:19497068-Antibodies, Monoclonal,
pubmed-meshheading:19497068-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:19497068-Benzimidazoles,
pubmed-meshheading:19497068-Drug Therapy, Combination,
pubmed-meshheading:19497068-Female,
pubmed-meshheading:19497068-Fumarates,
pubmed-meshheading:19497068-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:19497068-Humans,
pubmed-meshheading:19497068-Hypertension, Renal,
pubmed-meshheading:19497068-Kidney Transplantation,
pubmed-meshheading:19497068-Nephrotic Syndrome,
pubmed-meshheading:19497068-Plasma Exchange,
pubmed-meshheading:19497068-Proteinuria,
pubmed-meshheading:19497068-Ramipril,
pubmed-meshheading:19497068-Recurrence,
pubmed-meshheading:19497068-Renin,
pubmed-meshheading:19497068-Renin-Angiotensin System,
pubmed-meshheading:19497068-Tetrazoles
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pubmed:year |
2009
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pubmed:articleTitle |
Effect of a triple blockade of the renin-angiotensin-system in recurrent focal segmental glomerulosclerosis after kidney transplantation.
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pubmed:affiliation |
Department of Nephrology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany.
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pubmed:publicationType |
Journal Article,
Case Reports
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