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pubmed-article:19496758pubmed:abstractTextImmediate allergic hypersensitivity reactions with fentanyl are rarely reported. We diagnosed a presumably IgE-mediated allergic hypersensitivity reaction comprising generalized erythema and bronchospasm 4 h after the first-time application of transdermal fentanyl. Prick test remained negative with fentanyl whereas an intradermal test (IDT) with fentanyl was positive (dilution 10(-2)). Cross-reactivity was found with sufentanil but not with remifentanil. The diagnosis was supported by the clinical history and a positive IDT with fentanyl. This case report confirms the need for a systematic allergological investigation in case of immediate hypersensitivity reactions for all drugs and all modes of administration.lld:pubmed
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pubmed-article:19496758pubmed:articleTitleAn anaphylactic reaction to transdermal delivered fentanyl.lld:pubmed
pubmed-article:19496758pubmed:affiliationService d'Anesthésie-Réanimation Chirurgicale & SAMU de Paris, Hôpital Necker-Enfants Malades, AP-HP, Université Paris Descartes, Paris, France. pascale.dewachter@yahoo.frlld:pubmed
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