Linked Life Data

19496099

Source:http://linkedlifedata.com/resource/pubmed/id/19496099

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
28
pubmed:dateCreated
2009-7-14
pubmed:abstractText
Luminescent, mesoporous, and bioactive europium-doped hydroxyapatite (HAp:Eu(3+)) nanofibers and microbelts have been prepared by a combination of sol-gel and electrospinning processes with a cationic surfactant as template. The obtained multifunctional hydroxyapatite nanofibers and microbelts, which have mesoporous structure and red luminescence, were tested as drug carriers by investigating their drug-storage/release properties with ibuprofen (IBU) as model drug. X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution (HR) TEM, FTIR spectroscopy, N(2) adsorption/desorption, photoluminescence (PL) spectra, and UV/Vis spectroscopy were used to characterize the structural, morphological, textural, and optical properties of the resulting samples. The results reveal that the multifunctional hydroxyapatites exhibit irregular mesostructure, and have fiberlike and beltlike morphologies with sizes of several hundred nanometers in width and several millimeters in length. The IBU-loaded HAp:Eu(3+) system shows red luminescence of Eu(3+) ((5)D(0)-(7)F(0,1,2)) under UV irradiation and controlled release of IBU. In addition, the emission intensity of Eu(3+) in the drug carrier system varies with the released amount of IBU, and thus drug release can be easily tracked and monitored by the change in luminescence intensity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1521-3765
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6973-82
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Multifunctional hydroxyapatite nanofibers and microbelts as drug carriers.
pubmed:affiliation
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't