Linked Life Data

19496056

Source:http://linkedlifedata.com/resource/pubmed/id/19496056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-6-4
pubmed:abstractText
Comparison of DNA sequences from different species is a fundamental method for identifying functional elements, such as exons or enhancers, as they tend to exhibit significant sequence similarity due to purifying selection. Availability of whole-genome sequences for a constantly growing number of organisms makes identification of such elements within these genomes possible. There are two distinct phases in comparisons of genomic sequences: in the first, the sequences are aligned, and in the second, the resulting alignments are analyzed to find conservation signals that may be indicative of functional regions. Due to the considerable length of alignments, good visual representation techniques are a necessity for effective isolation of regions of interest. The VISTA family of tools provides biomedical investigators with a unified framework for the alignment of long genomic sequences and whole-genome assemblies, interactive visual analysis of alignments along with functional annotation, and many other comparative genomics capabilities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1934-340X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
Chapter 10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
Unit 10.6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Obtaining comparative genomic data with the VISTA family of computational tools.
pubmed:affiliation
Lawrence Berkeley National Laboratory, Berkeley, California, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural