Source:http://linkedlifedata.com/resource/pubmed/id/19494437
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2009-6-4
|
| pubmed:abstractText |
The distribution of the MCP-1 A-2518G single nucleotide polymorphisms (SNP) was analyzed in a population of 212 patients with frontotemporal lobar degeneration (FTLD) compared with 203 age-matched controls. A significantly decreased allelic frequency of the G allele in patients compared with controls was observed (21.1 versus 29.3%, P = 0.011, OR: 0.59, CI: 0.40-0.87). Stratifying according to gender, the association was maintained in male patients versus male controls (17.8 versus 29.4%, P = 0.016, OR = 0.46, 95% CI: 0.25-0.84), but not in female patients compared with female controls (23.5 versus 29.2%, P > 0.05). The frequency of apolipoprotein E epsilon4 carriers was increased in patients (26.4 versus 13.8%, P = 0.0015, OR: 2.24, 95% CI: 1.37-3.67). Apolipoprotein E status did not influence the distribution of the A-2518G SNP. Monocyte chemotactic protein (MCP)-1 levels were determined in cerebrospinal fluid (CSF) collected from 23 patients and 17 controls. MCP-1 CSF levels were increased in patients compared with controls (449.01 +/- 27.57 versus 364.19 +/- 23.75 pg/ml, P = 0.011). Stratifying patients according to the presence of the polymorphic allele, significantly increased CSF MCP-1 levels were observed in carriers of the G allele compared with non-carriers (502.21 +/- 44.57 versus 395.87 +/- 21.92 pg/ml, P = 0.045). The MCP-1 A-2518G SNP acts as protective factor for sporadic FTLD, possibly by influencing MCP-1 production.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1387-2877
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| pubmed:author |
pubmed-author:BenussiLuisaL,
pubmed-author:BinettiGiulianoG,
pubmed-author:BresolinNereoN,
pubmed-author:CappaStefanoS,
pubmed-author:ClericiFrancescaF,
pubmed-author:CortiniFrancescaF,
pubmed-author:FenoglioChiaraC,
pubmed-author:GalimbertiDanielaD,
pubmed-author:MarconeAlessandraA,
pubmed-author:MarianiClaudioC,
pubmed-author:PeriniLucaL,
pubmed-author:RestelliIlariaI,
pubmed-author:ScalabriniDiegoD,
pubmed-author:ScarpiniElioE,
pubmed-author:VenturelliElianaE,
pubmed-author:VillaChiaraC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
125-33
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| pubmed:dateRevised |
2010-10-22
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| pubmed:meshHeading |
pubmed-meshheading:19494437-Aged,
pubmed-meshheading:19494437-Case-Control Studies,
pubmed-meshheading:19494437-Chemokine CCL2,
pubmed-meshheading:19494437-DNA Mutational Analysis,
pubmed-meshheading:19494437-Dementia,
pubmed-meshheading:19494437-Female,
pubmed-meshheading:19494437-Gene Frequency,
pubmed-meshheading:19494437-Genetic Predisposition to Disease,
pubmed-meshheading:19494437-Genotype,
pubmed-meshheading:19494437-Humans,
pubmed-meshheading:19494437-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:19494437-Male,
pubmed-meshheading:19494437-Middle Aged,
pubmed-meshheading:19494437-Polymorphism, Single Nucleotide,
pubmed-meshheading:19494437-Sex Factors
|
| pubmed:year |
2009
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| pubmed:articleTitle |
MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels.
|
| pubmed:affiliation |
Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy. daniela.galimberti@unimi.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|