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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-6-4
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pubmed:abstractText |
Arthritogenic T lymphocytes with common T cell receptor (TCR) Vbeta clonotypes, infiltrating in the articulars of rheumatoid arthritis (RA) patients, play a central role in the pathogenesis of RA. TCR Vbeta5.2 and TCR Vbeta8.2 are the main pathogenic T cell clonotypes in the course of collagen-induced arthritis (CIA) progression in Lewis rats. To investigate a TCR-based immunotherapy for RA, we constructed recombinant DNA vaccines encoding TCR Vbeta5.2 and TCR Vbeta8.2, and evaluated the inhibitive effects of the two vaccines on CIA rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0366-6999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1039-48
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pubmed:meshHeading |
pubmed-meshheading:19493438-Animals,
pubmed-meshheading:19493438-Arthritis, Experimental,
pubmed-meshheading:19493438-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19493438-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19493438-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19493438-Female,
pubmed-meshheading:19493438-Flow Cytometry,
pubmed-meshheading:19493438-Immunohistochemistry,
pubmed-meshheading:19493438-Interferon-gamma,
pubmed-meshheading:19493438-Interleukin-4,
pubmed-meshheading:19493438-Muscles,
pubmed-meshheading:19493438-Peptide Fragments,
pubmed-meshheading:19493438-Rats,
pubmed-meshheading:19493438-Rats, Inbred Lew,
pubmed-meshheading:19493438-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:19493438-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19493438-Vaccines, DNA
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of collagen-induced arthritis by DNA vaccines encoding TCR Vbeta5.2 and TCR Vbeta8.2.
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pubmed:affiliation |
Department of Transfusion, Aerospace Center Hospital, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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