Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-10-26
pubmed:abstractText
There is good evidence from animal studies for segregation in the processing of non-nociceptive and nociceptive information within the trigeminal brainstem sensory nuclear complex. However, it remains unknown whether a similar segregation occurs in humans, and a recent tract tracing study suggests that this segregation may not exist. We used functional magnetic resonance imaging (fMRI) to define and compare activity patterns of the trigeminal brainstem nuclear complex during non-noxious and noxious cutaneous and non-noxious and noxious muscle orofacial stimulation in humans. We found that during cutaneous pain, signal intensity increased within the entire rostrocaudal extent of the spinal trigeminal nucleus (SpV), encompassing the ipsilateral oralis (SpVo), interpolaris (SpVi) and caudalis (SpVc) subdivisions. In contrast, muscle pain did not activate SpVi, but instead activated a discrete region of the ipsilateral SpVo and SpVc. Further, muscle noxious stimulation activated a region of the ipsilateral lateral pons in the region of the trigeminal principal sensory nucleus (Vp). Innocuous orofacial stimulation (lip brushing) also evoked a significant increase in signal intensity in the ipsilateral Vp; however, non-noxious muscle stimulation showed no increase in signal in this area. The data reveal that orofacial cutaneous and muscle nociceptive information and innocuous cutaneous stimulation are differentially represented within the trigeminal nuclear complex. It is well established that cutaneous and muscle noxious stimuli evoke different perceptual, behavioural and cardiovascular changes. We speculate that the differential activation evoked by cutaneous and muscle noxious stimuli within the trigeminal sensory complex may contribute to the neural basis for these differences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1097-0193
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3772-82
pubmed:meshHeading
pubmed-meshheading:19492300-Adult, pubmed-meshheading:19492300-Afferent Pathways, pubmed-meshheading:19492300-Brain Mapping, pubmed-meshheading:19492300-Brain Stem, pubmed-meshheading:19492300-Facial Pain, pubmed-meshheading:19492300-Female, pubmed-meshheading:19492300-Functional Laterality, pubmed-meshheading:19492300-Humans, pubmed-meshheading:19492300-Image Processing, Computer-Assisted, pubmed-meshheading:19492300-Lip, pubmed-meshheading:19492300-Magnetic Resonance Imaging, pubmed-meshheading:19492300-Male, pubmed-meshheading:19492300-Middle Aged, pubmed-meshheading:19492300-Oxygen, pubmed-meshheading:19492300-Pain Measurement, pubmed-meshheading:19492300-Pain Threshold, pubmed-meshheading:19492300-Physical Stimulation, pubmed-meshheading:19492300-Psychophysics, pubmed-meshheading:19492300-Saline Solution, Hypertonic, pubmed-meshheading:19492300-Trigeminal Nuclei
pubmed:year
2009
pubmed:articleTitle
Differential activation of the human trigeminal nuclear complex by noxious and non-noxious orofacial stimulation.
pubmed:affiliation
Department of Anatomy and Histology, University of Sydney, New South Wales, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't