| pubmed-article:19492158 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C0034848 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C0032143 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C0030190 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C1537399 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C1336635 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C1539233 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C1979925 | lld:lifeskim |
| pubmed-article:19492158 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19492158 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19492158 | pubmed:dateCreated | 2009-6-3 | lld:pubmed |
| pubmed-article:19492158 | pubmed:abstractText | Tissue-type plasminogen activator (t-PA) and its specific inhibitor plasminogen activator inhibitor-1 (PAI-1) are key mediators in the regulation of fibrin generation and fibrinolysis. Mesothelial cells (MC) line the inner surface of serosal cavities and are a source of procoagulant and fibrinolytic system components. Viral inflammation and infection of MC are a major problem in several organ systems including pleura, pericardium and peritoneum. MC express the viral receptors Toll-like receptor 3 (TLR3), RIG-I and MDA5. TLRs recognise molecular patterns associated with microbial pathogens and induce an immune response. TLR3 recognises dsRNA of viral origin as exemplified by poly (I:C) RNA, a synthetic analogue of viral dsRNA. The helicases RIG-I and MDA5 may also act as sensors of viral infections. Activation of these receptors by poly (I:C) RNA leads to an time- and dose-dependent increase of mesothelial PAI-1 synthesis and a decrease of t-PA expression. To show the specific effect of viral receptors knockdown experiments with siRNA specific for TLR3, RIG-I and MDA5 were performed. This finding of viral induced changes of t-PA and PAI-1 synthesis may indicate a novel link between viral infections and formation of mesothelial fibrin deposits and progression of viral associated disease of the pleura, peritoneum and pericardium. | lld:pubmed |
| pubmed-article:19492158 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19492158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19492158 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19492158 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19492158 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:SitterThomasT | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:MussackThomas... | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:WörnleMarkusM | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:LadurnerRolan... | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:SauterMatthia... | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:KastenmüllerK... | lld:pubmed |
| pubmed-article:19492158 | pubmed:author | pubmed-author:RibeiroAndrea... | lld:pubmed |
| pubmed-article:19492158 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19492158 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:19492158 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19492158 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19492158 | pubmed:pagination | 1128-37 | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
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| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:meshHeading | pubmed-meshheading:19492158... | lld:pubmed |
| pubmed-article:19492158 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19492158 | pubmed:articleTitle | Role of viral receptors TLR3, RIG-I and MDA5 in mesothelial tissue-type plasminogen activator and plasminogen activator inhibitor-1 synthesis. | lld:pubmed |
| pubmed-article:19492158 | pubmed:affiliation | Medical Policlinic, Ludwig-Maximillians-University, Munich, Germany. Markus.Woernle@med.uni-muenchen.de | lld:pubmed |
| pubmed-article:19492158 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19492158 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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