| pubmed-article:19492058 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19492058 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:19492058 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:19492058 | lifeskim:mentions | umls-concept:C1505172 | lld:lifeskim |
| pubmed-article:19492058 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:19492058 | lifeskim:mentions | umls-concept:C1521805 | lld:lifeskim |
| pubmed-article:19492058 | lifeskim:mentions | umls-concept:C0045186 | lld:lifeskim |
| pubmed-article:19492058 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19492058 | pubmed:dateCreated | 2009-6-3 | lld:pubmed |
| pubmed-article:19492058 | pubmed:abstractText | Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair with an A in addition to normal base pairing of 8-oxoG(anti) with a C. Human DNA polymerase kappa (Polkappa) is a member of the newly discovered Y-family of DNA polymerases that possess the ability to replicate through DNA lesions. To understand the basis of Polkappa's preference for insertion of an A opposite 8-oxoG lesion, we have solved the structure of Polkappa in ternary complex with a template-primer presenting 8-oxoG in the active site and with dATP as the incoming nucleotide. | lld:pubmed |
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| pubmed-article:19492058 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19492058 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19492058 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19492058 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:JohnsonRobert... | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:PrakashLouise... | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:PrakashSatyaS | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:AggarwalAneel... | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:LoneSamerS | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:SwanMichael... | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:Vasquez-Del... | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:SilversteinTi... | lld:pubmed |
| pubmed-article:19492058 | pubmed:author | pubmed-author:ChoudhuryJaya... | lld:pubmed |
| pubmed-article:19492058 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19492058 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:19492058 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19492058 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19492058 | pubmed:pagination | e5766 | lld:pubmed |
| pubmed-article:19492058 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19492058 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19492058 | pubmed:articleTitle | Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. | lld:pubmed |
| pubmed-article:19492058 | pubmed:affiliation | Department of Structural & Chemical Biology, Mount Sinai School of Medicine, New York, NY, USA. | lld:pubmed |
| pubmed-article:19492058 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19492058 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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