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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-6-3
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pubmed:abstractText |
Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair with an A in addition to normal base pairing of 8-oxoG(anti) with a C. Human DNA polymerase kappa (Polkappa) is a member of the newly discovered Y-family of DNA polymerases that possess the ability to replicate through DNA lesions. To understand the basis of Polkappa's preference for insertion of an A opposite 8-oxoG lesion, we have solved the structure of Polkappa in ternary complex with a template-primer presenting 8-oxoG in the active site and with dATP as the incoming nucleotide.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e5766
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19492058-Adenosine Triphosphate,
pubmed-meshheading:19492058-Catalytic Domain,
pubmed-meshheading:19492058-Crystallization,
pubmed-meshheading:19492058-DNA,
pubmed-meshheading:19492058-DNA Damage,
pubmed-meshheading:19492058-DNA Replication,
pubmed-meshheading:19492058-DNA-Directed DNA Polymerase,
pubmed-meshheading:19492058-Free Radicals,
pubmed-meshheading:19492058-Guanine,
pubmed-meshheading:19492058-Humans,
pubmed-meshheading:19492058-Kinetics,
pubmed-meshheading:19492058-Models, Genetic,
pubmed-meshheading:19492058-Nucleotides,
pubmed-meshheading:19492058-Protein Conformation
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pubmed:year |
2009
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pubmed:articleTitle |
Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.
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pubmed:affiliation |
Department of Structural & Chemical Biology, Mount Sinai School of Medicine, New York, NY, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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