Linked Life Data

19491384

Source:http://linkedlifedata.com/resource/pubmed/id/19491384

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
73
pubmed:dateCreated
2009-6-3
pubmed:abstractText
Posttranslational modifications of clock proteins are crucial to generating proper circadian rhythms of the correct length and amplitude. Here, we show that the protein kinase CK2 (casein kinase 2) plays a role in regulating the mammalian circadian clock. We found that inhibiting CK2 activity resulted in a decrease in the amplitude and an increase in the period of oscillations in circadian gene expression. CK2 specifically bound and phosphorylated PERIOD2 (PER2) and collaborated with the protein kinase CKIepsilon to promote PER2 degradation. We also identified a CK2 phosphorylation site (serine-53) in PER2, whose phosphorylation played a role in fine-tuning circadian rhythms and regulating PER2 stability but was dispensable for the cooperative effect of CK2 and CKIepsilon. Thus, our study identifies CK2 as a regulatory element of mammalian circadian rhythms and uncovers a role for CK2 in PER2 degradation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1937-9145
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
ra26
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.
pubmed:affiliation
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
pubmed:publicationType
Journal Article