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rdf:type |
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lifeskim:mentions |
umls-concept:C0003980,
umls-concept:C0017431,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0022877,
umls-concept:C0031809,
umls-concept:C0039593,
umls-concept:C0078988,
umls-concept:C0332306,
umls-concept:C0683598,
umls-concept:C1257890,
umls-concept:C1274040,
umls-concept:C1292734,
umls-concept:C1519193,
umls-concept:C1522326
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pubmed:issue |
2
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pubmed:dateCreated |
2009-6-3
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pubmed:abstractText |
The TREAT Asia (Therapeutics, Research, Education, and AIDS Training in Asia) Network is building capacity for Human Immunodeficiency Virus Type-1 (HIV-1) drug resistance testing in the region. The objective of the TREAT Asia Quality Assessment Scheme - designated TAQAS - is to standardize HIV-1 genotypic resistance testing (HIV genotyping) among laboratories to permit rigorous comparison of results from different clinics and testing centres. TAQAS has evaluated three panels of HIV-1-positive plasma from clinical material or low-passage, culture supernatant for up to 10 Asian laboratories. Laboratory participants used their standard protocols to perform HIV genotyping. Assessment was in comparison to a target genotype derived from all participants and the reference laboratory's result. Agreement between most participants at the edited nucleotide sequence level was high (>98%). Most participants performed to the reference laboratory standard in detection of drug resistance mutations (DRMs). However, there was variation in the detection of nucleotide mixtures (0-83%) and a significant correlation with the detection of DRMs (p<0.01). Interpretation of antiretroviral resistance showed approximately 70% agreement among participants when different interpretation systems were used but >90% agreement with a common interpretation system, within the Stanford University Drug Resistance Database. Using the principles of external quality assessment and a reference laboratory, TAQAS has demonstrated high quality HIV genotyping results from Asian laboratories.
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pubmed:grant |
|
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-10364600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-10815085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-11283081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-11376051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-11724853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-11860670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-11932232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12149361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12467778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12517853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12534963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12792349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12830416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12843019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12843074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-12904355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-14575971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-15000579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-16386109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-16436728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-16946457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-17219736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-17515643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-17885293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-7699047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-9230356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19490972-9820578
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1879-0984
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pubmed:author |
pubmed-author:ChenYi-Ming ArthurYM,
pubmed-author:CunninghamPhilipP,
pubmed-author:DaxElizabeth MEM,
pubmed-author:DeLongAllisonA,
pubmed-author:FrostKevinK,
pubmed-author:KantorRamiR,
pubmed-author:KatzensteinDavidD,
pubmed-author:LandSallyS,
pubmed-author:LawMatthewM,
pubmed-author:OkaShinichiS,
pubmed-author:SayerDavidD,
pubmed-author:SmithJefferyJ,
pubmed-author:TAQAS Laboratory Network,
pubmed-author:ZhouJialunJ
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pubmed:issnType |
Electronic
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-93
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
TREAT Asia Quality Assessment Scheme (TAQAS) to standardize the outcome of HIV genotypic resistance testing in a group of Asian laboratories.
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pubmed:affiliation |
National Serology Reference Laboratory, Australia. sally@nrl.gov.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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