Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-8-7
pubmed:abstractText
Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons from aged controls was investigated. From 31 single cytochrome c oxidase normal SN neurons, only one clonally expanded mtDNA point mutation was identified, suggesting in these neurons mtDNA point mutations occur rarely, whereas mtDNA deletions are frequently observed. This contrasts observations in mitotic tissues and suggests that different forms of mtDNA maintenance may exist in these two cell types.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-10508508, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-11136709, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-11470889, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-11943860, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-12031622, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-1402908, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-14597761, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-15164064, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-16020738, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-16381973, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-16604072, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-16604074, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-17886296, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-18179904, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-18305478, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-18311139, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-18800376, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-7219534, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-9296365, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-9469836, http://linkedlifedata.com/resource/pubmed/commentcorrection/19489744-9485063
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1474-9726
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
496-8
pubmed:dateRevised
2011-1-5
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons.
pubmed:affiliation
Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't