Source:http://linkedlifedata.com/resource/pubmed/id/19489023
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2009-6-30
|
| pubmed:abstractText |
With contrasting observations on the effects of beta-catenin on hematopoietic stem cells (HSCs), the precise role of Wnt/beta-catenin signals on HSC regulation remains unclear. Here, we show a distinct mode of Wnt/beta-catenin signal that can regulate HSCs in a stroma-dependent manner. Stabilization of beta-catenin in the bone marrow stromal cells promoted maintenance and self-renewal of HSCs in a contact-dependent manner, whereas direct stabilization in hematopoietic cells caused loss of HSCs. Interestingly, canonical Wnt receptors and beta-catenin accumulation were predominantly enriched in the stromal rather than the hematopoietic compartment of bone marrows. Moreover, the active form of beta-catenin accumulated selectively in the trabecular endosteum in "Wnt 3a-stimulated" or "irradiation-stressed," but not in "steady-state" marrows. Notably, notch ligands were induced in Wnt/beta-catenin activated bone marrow stroma and downstream notch signal activation was seen in the HSCs in contact with the activated stroma. Taken together, Wnt/beta-catenin activated stroma and their cross-talk with HSCs may function as a physiologically regulated microenvironmental cue for HSC self-renewal in the stem cell niche.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1549-4918
|
| pubmed:author |
pubmed-author:ChuIn-SunIS,
pubmed-author:JhoEek-HoonEH,
pubmed-author:KangYoung-JuYJ,
pubmed-author:KimHanjunH,
pubmed-author:KimJin-AJA,
pubmed-author:KimMyungshinM,
pubmed-author:LeeJun-SeongJS,
pubmed-author:LeemSun-HeeSH,
pubmed-author:OhIl-HoanIH,
pubmed-author:ParkGyeongsinG,
pubmed-author:ParkYoung-OkYO
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1318-29
|
| pubmed:meshHeading |
pubmed-meshheading:19489023-Animals,
pubmed-meshheading:19489023-Blotting, Western,
pubmed-meshheading:19489023-Bone Marrow Cells,
pubmed-meshheading:19489023-Cell Proliferation,
pubmed-meshheading:19489023-Flow Cytometry,
pubmed-meshheading:19489023-Hematopoietic Stem Cells,
pubmed-meshheading:19489023-Immunohistochemistry,
pubmed-meshheading:19489023-Mice,
pubmed-meshheading:19489023-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19489023-Receptor Cross-Talk,
pubmed-meshheading:19489023-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19489023-Signal Transduction,
pubmed-meshheading:19489023-Stem Cell Niche,
pubmed-meshheading:19489023-Stromal Cells,
pubmed-meshheading:19489023-Wnt Proteins,
pubmed-meshheading:19489023-beta Catenin
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche.
|
| pubmed:affiliation |
Catholic Cell Therapy Center and Department of Cellular Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|