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rdf:type |
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lifeskim:mentions |
umls-concept:C0007158,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0031330,
umls-concept:C0086418,
umls-concept:C0597298,
umls-concept:C1280500,
umls-concept:C1446409,
umls-concept:C1547011,
umls-concept:C1879746,
umls-concept:C2744205
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-21
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pubmed:abstractText |
The Na,K-ATPase (NKA) is necessary for maintaining the resting membrane potential by transporting Na and K ions across the cell membrane. Although its 3 isoforms expressed in human heart (alpha1beta1, alpha2beta1, and alpha3beta1) possess similar biochemical properties, their specific functions in human tissues remain unknown. In our search for an isoform-specific agent, which can serve to identify isoform-specific functions, we examined 8-methoxycoumestrol in its ability to inhibit the NKA and to produce inotropism in connection with the possibility to identify the NKA isoform-specific functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1533-4023
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pubmed:author |
pubmed-author:AdamCC,
pubmed-author:CostaP R RPR,
pubmed-author:DiedrichsHH,
pubmed-author:HauckCC,
pubmed-author:Müller-EhmsenJJ,
pubmed-author:NoëlFF,
pubmed-author:PôçasE S CES,
pubmed-author:PotterTT,
pubmed-author:ReuterHH,
pubmed-author:WahlersTT,
pubmed-author:WittwerTT,
pubmed-author:da SilvaA J MAJ
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10-5
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pubmed:meshHeading |
pubmed-meshheading:19487957-Aged,
pubmed-meshheading:19487957-Cardiac Glycosides,
pubmed-meshheading:19487957-Coumestrol,
pubmed-meshheading:19487957-Dose-Response Relationship, Drug,
pubmed-meshheading:19487957-Enzyme Inhibitors,
pubmed-meshheading:19487957-Heart Atria,
pubmed-meshheading:19487957-Humans,
pubmed-meshheading:19487957-Inhibitory Concentration 50,
pubmed-meshheading:19487957-Isoenzymes,
pubmed-meshheading:19487957-Kidney,
pubmed-meshheading:19487957-Male,
pubmed-meshheading:19487957-Middle Aged,
pubmed-meshheading:19487957-Molecular Structure,
pubmed-meshheading:19487957-Muscle Contraction,
pubmed-meshheading:19487957-Myocardium,
pubmed-meshheading:19487957-Nephrectomy,
pubmed-meshheading:19487957-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:19487957-Temperature,
pubmed-meshheading:19487957-Time Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology.
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pubmed:affiliation |
Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Köln 50924, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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