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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-9-23
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pubmed:abstractText |
Expression of the anti-apoptotic myeloid cell leukemia-1 (MCL-1) gene is a novel prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL). Vascular and endothelial growth factor (VEGF) and interleukin-6 (IL-6) are able to upregulate MCL-1 via autocrine signaling loops. In 88 B-CLL patients, we found a strong correlation of MCL-1 gene expression with VEGF (P<10(-7)) but not with IL-6 mRNA levels. VEGF but not IL-6 expression influenced patient prognosis. VEGF may be a positive autocrine in vivo regulator of MCL-1 in B-CLL. Inhibition of VEGF and its signaling may prove to be useful in the treatment of B-CLL patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1873-5835
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pubmed:author |
pubmed-author:BayJacques-OlivierJO,
pubmed-author:ChautardEmmanuelE,
pubmed-author:DaviFrédéricF,
pubmed-author:DighieroGuillaumeG,
pubmed-author:GouasLaetitiaL,
pubmed-author:GoumyCaroleC,
pubmed-author:KwiatkowskiFabriceF,
pubmed-author:TchirkovAndreiA,
pubmed-author:TournilhacOlivierO,
pubmed-author:VéronèseLaurenL,
pubmed-author:VagoPhilippeP,
pubmed-author:VerrellePierreP,
pubmed-author:Veyrat-MassonRichardR
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1623-6
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pubmed:meshHeading |
pubmed-meshheading:19487028-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19487028-Interleukin-6,
pubmed-meshheading:19487028-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:19487028-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19487028-RNA, Messenger,
pubmed-meshheading:19487028-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19487028-Signal Transduction,
pubmed-meshheading:19487028-Vascular Endothelial Growth Factor A
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pubmed:year |
2009
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pubmed:articleTitle |
Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia.
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pubmed:affiliation |
Univ Clermont 1, Fac Médecine, Histologie Embryologie Cytogénétique, Clermont-Ferrand F-63001, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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