|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2009-6-2
|
|
pubmed:abstractText |
Three-quarters of eukaryotic DNA are wrapped around protein cylinders forming so-called nucleosomes that block the access to the genetic information. Nucleosomes need therefore to be repositioned, either passively (by thermal fluctuations) or actively (by molecular motors). Here we introduce a theoretical model that allows us to study the interplay between a motor protein that moves along DNA (e.g., an RNA polymerase) and a nucleosome that it encounters on its way. We aim at describing the displacement mechanisms of the nucleosome and the motor protein on a microscopic level to understand better the intricate interplay between the active step of the motor and the nucleosome-repositioning step. Different motor types (Brownian ratchet versus power-stroke mechanism) that perform very similarly under a constant load are shown to have very different nucleosome repositioning capacities.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-10499798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-10843841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-10851197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-11328188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-11854495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-12144782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-12666181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-12719249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-14611559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15016367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15016373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15016374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15245260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15504401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15522289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15580276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15680325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-15903965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-1639066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-16862119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-17043216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-17698962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-17930799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-17984961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-17994031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-7490738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-7502073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-7690028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-7781609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-8293470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-8995520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-9305837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-9395401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-9512017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19486663-9794753
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1542-0086
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
3
|
|
pubmed:volume |
96
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4387-98
|
|
pubmed:dateRevised |
2010-9-27
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Active nucleosome displacement: a theoretical approach.
|
|
pubmed:affiliation |
Physics Department, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran.
|
|
pubmed:publicationType |
Journal Article
|
