Source:http://linkedlifedata.com/resource/pubmed/id/19484668
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-6-1
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| pubmed:abstractText |
The direct effect of gastro-esophageal reflux (GER) on lung function is still debated. Objective. To investigate the role of esophageal acidification in affecting airway response to MCh in GER-related versus atopic asthmatics and to assess specificity and sensitivity of events. Subjects. A total of 56 never-smoking, mild asthmatics: 27 non-atopic asthmatics and acid GER (GER+ve) and 29 atopic asthmatics without any GER (GER-ve). Methods. Each subject performed an MCh challenge in baseline (MCh(b)), and 30 minutes after an acid drink (125 mL at pH = 2; MCh(ac)), one day apart. PD(20)FEV(1) MCh(b) and MCh(ac) were compared by estimating the area under the ROC curve (AU-ROC). Results. GER+ve and GER-ve subjects (well matched in baseline) had a different duration of esophageal acid contact (24-hour monitoring; pH-24h AU(4)), and PD(20)FEV(1) MCh(ac) (both p < 0.001). AU-ROC was 86.3% (76% to 97%, 95%CI). Sensitivity and specificity of changes were 82.8% (72.9% to 92.7%, 95%CI) and 85.2% (75.9% to 94.5%, 95%CI), respectively. The difference in MCh threshold that maximized both the sensitivity and specificity level was 100 mu g. Conclusions. The esophageal acidification identified GER-related asthma with a good level of both sensitivity and specificity by enhancing the MCh response only in the presence of acid GER. Data are supporting the effectiveness of this procedure for clinical purposes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1532-4303
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
46
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
351-5
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| pubmed:meshHeading |
pubmed-meshheading:19484668-Adult,
pubmed-meshheading:19484668-Age Distribution,
pubmed-meshheading:19484668-Area Under Curve,
pubmed-meshheading:19484668-Asthma,
pubmed-meshheading:19484668-Bronchial Hyperreactivity,
pubmed-meshheading:19484668-Bronchial Provocation Tests,
pubmed-meshheading:19484668-Case-Control Studies,
pubmed-meshheading:19484668-Comorbidity,
pubmed-meshheading:19484668-Confidence Intervals,
pubmed-meshheading:19484668-Esophageal pH Monitoring,
pubmed-meshheading:19484668-Female,
pubmed-meshheading:19484668-Forced Expiratory Volume,
pubmed-meshheading:19484668-Gastroesophageal Reflux,
pubmed-meshheading:19484668-Humans,
pubmed-meshheading:19484668-Italy,
pubmed-meshheading:19484668-Male,
pubmed-meshheading:19484668-Manometry,
pubmed-meshheading:19484668-Methacholine Chloride,
pubmed-meshheading:19484668-Middle Aged,
pubmed-meshheading:19484668-Prevalence,
pubmed-meshheading:19484668-Prognosis,
pubmed-meshheading:19484668-ROC Curve,
pubmed-meshheading:19484668-Reference Values,
pubmed-meshheading:19484668-Respiratory Function Tests,
pubmed-meshheading:19484668-Risk Assessment,
pubmed-meshheading:19484668-Severity of Illness Index,
pubmed-meshheading:19484668-Sex Distribution
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| pubmed:year |
2009
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| pubmed:articleTitle |
A MCh test pre-post esophageal acidification in detecting GER-related asthma.
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| pubmed:affiliation |
Lung Department, Ospedale Orlandi, Bussolengo, Italy. rdalnegro@ulss22.ven.it
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| pubmed:publicationType |
Journal Article,
Comparative Study
|