Linked Life Data

19483191

Source:http://linkedlifedata.com/resource/pubmed/id/19483191

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-7-30
pubmed:abstractText
Decoy receptor 3 (DcR3), a member of tumor necrosis factor receptor superfamily, has been implicated in tumorigenesis through its abilities to modulate immune responses and induce angiogenesis. Epstein-Barr virus (EBV), a ubiquitous gamma-herpesvirus, is associated with malignancies including nasopharyngeal carcinoma (NPC). Previous studies show that DcR3 is overexpressed in EBV-positive lymphomas and Rta, an EBV transcription activator, can upregulate DcR3 in Burkitt lymphoma cell lines. However, DcR3 expression has not been demonstrated in EBV-associated NPC nor have there been any EBV latent genes linked to DcR3 upregulation. Here, we showed DcR3 was overexpressed in NPC. Higher DcR3 expression score and DcR3-positive rate were found in metastatic NPC than in primary NPC tissues, suggesting DcR3 may enhance cell metastatic potential. This hypothesis is supported by our observation that NPC HONE-1 cells overexpressing DcR3 exhibited significant higher migration and invasion abilities in vitro. We found besides Rta, EBV latent membrane protein (LMP) 1 can upregulate DcR3 via nuclear factor-kappaB and phosphatidylinositol 3-kinase-signaling events. Approximate 75% of LMP1-positive NPC tissues overexpressed DcR3, suggesting LMP1 may enhance DcR3 expression in vivo. Data herein suggested that increasing DcR3 expression by LMP1 not only helps EBV-associated cancer cells gain survival advantage by preventing host immune detection but also increases the chance of cancer metastasis by enhancing cell migration and invasion. All these DcR3-mediated events facilitate normal cells to gain cancer hallmarks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1460-2180
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1443-51
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19483191-Blotting, Western, pubmed-meshheading:19483191-Cell Movement, pubmed-meshheading:19483191-Chromatin Immunoprecipitation, pubmed-meshheading:19483191-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:19483191-Epstein-Barr Virus Infections, pubmed-meshheading:19483191-Gene Expression Regulation, pubmed-meshheading:19483191-Herpesvirus 4, Human, pubmed-meshheading:19483191-Humans, pubmed-meshheading:19483191-Immunoenzyme Techniques, pubmed-meshheading:19483191-Luciferases, pubmed-meshheading:19483191-NF-kappa B, pubmed-meshheading:19483191-Nasopharyngeal Neoplasms, pubmed-meshheading:19483191-Neoplasm Invasiveness, pubmed-meshheading:19483191-Phosphatidylinositol 3-Kinases, pubmed-meshheading:19483191-RNA, Messenger, pubmed-meshheading:19483191-Receptors, Tumor Necrosis Factor, Member 6b, pubmed-meshheading:19483191-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:19483191-Up-Regulation, pubmed-meshheading:19483191-Viral Matrix Proteins, pubmed-meshheading:19483191-Virus Latency
pubmed:year
2009
pubmed:articleTitle
Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion.
pubmed:affiliation
Institute of Microbiology and Immunology, National Yang-Ming University, No. 155, Section 2, Linong Street, Taipei 112, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't