19482684

Source:http://linkedlifedata.com/resource/pubmed/id/19482684

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0043343, umls-concept:C0439662, umls-concept:C1051658, umls-concept:C1880266
pubmed:dateCreated	2009-6-1
pubmed:abstractText	Amphibian populations are declining at an unprecedented rate worldwide. A number of declines have been linked to a pathogenic skin fungus, Batrachochytrium dendrobatidis. Although amphibians have robust immune defenses, many species seem to be very susceptible to infection by this fungus and to development of the lethal disease called chytridiomycosis. One species that is relatively resistant to B. dendrobatidis is Xenopus laevis. Because X. laevis has been used as a model for studies of immunity in amphibians and because it is relatively resistant to chytridiomycosis, it is a good model to examine immune defenses against B. dendrobatidis. Although much less is known about immune defenses in Bufo boreas, it serves as a second model species because it is very susceptible to B. dendrobatidis. Here we review what is known about innate antimicrobial peptide defenses in the skin and the development of immune responses following experimental immunization with heat-killed fungal cells. Development of an immunization protocol in X. laevis that induces effective defenses may suggest better strategies for protecting vulnerable species such as B. boreas.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101485241
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	1945-0524
pubmed:author	pubmed-author:CareyCynthiaC, pubmed-author:LivoLauren JLJ, pubmed-author:RamseyJeremy PJP, pubmed-author:ReinertLaura KLK, pubmed-author:Rollins-SmithLouise ALA, pubmed-author:WoodhamsDouglas CDC
pubmed:issnType	Electronic
pubmed:volume	1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	68-91
pubmed:meshHeading	pubmed-meshheading:19482684-Animals, pubmed-meshheading:19482684-Chytridiomycota, pubmed-meshheading:19482684-Xenopus laevis
pubmed:year	2009
pubmed:articleTitle	Immune defenses of Xenopus laevis against Batrachochytrium dendrobatidis.
pubmed:affiliation	Department of Microbiology and Immunology and Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 USA. louise.rollins-smith@vanderbilt.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't