|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-5-14
|
|
pubmed:abstractText |
Adiponectin (APN), which is an adipose tissue-derived hormone, is known as an anti-inflammatory cytokine. The effects of APN on the production of inflammatory mediators and hepatic injury during polymicrobial sepsis were evaluated using APN-knockout (KO) mice that had undergone a cecal ligation and puncture (CLP) and rosiglitazone, a selective peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, which increases the plasma APN concentration.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1095-8673
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
161
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
301-11
|
|
pubmed:meshHeading |
pubmed-meshheading:19481767-Adiponectin,
pubmed-meshheading:19481767-Alanine Transaminase,
pubmed-meshheading:19481767-Animals,
pubmed-meshheading:19481767-Disease Models, Animal,
pubmed-meshheading:19481767-Fibrinolytic Agents,
pubmed-meshheading:19481767-Inflammation,
pubmed-meshheading:19481767-Inflammation Mediators,
pubmed-meshheading:19481767-Interleukin-6,
pubmed-meshheading:19481767-Liver,
pubmed-meshheading:19481767-Male,
pubmed-meshheading:19481767-Mice,
pubmed-meshheading:19481767-Mice, Inbred C57BL,
pubmed-meshheading:19481767-Mice, Knockout,
pubmed-meshheading:19481767-Microscopy, Confocal,
pubmed-meshheading:19481767-Punctures,
pubmed-meshheading:19481767-Receptors, CCR2,
pubmed-meshheading:19481767-Sepsis,
pubmed-meshheading:19481767-Shock, Septic,
pubmed-meshheading:19481767-Thiazolidinediones,
pubmed-meshheading:19481767-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis.
|
|
pubmed:affiliation |
Department of Surgery, Shiga University of Medical Science, Shiga, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
