Linked Life Data

19481337

Source:http://linkedlifedata.com/resource/pubmed/id/19481337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-10-20
pubmed:abstractText
Genetic variations in DNA repair genes are thought to modify DNA repair capacity and suggested to be related to cancer risk. However, epidemiological results have been inconsistent. In this meta-analysis, we assessed reported studies of association between polymorphisms of X-ray repair cross complementing group 1 (XRCC1) codon 399 and 194, and lung cancer risk. We found decreased lung cancer risk among subjects carrying XRCC1 codon 194 Arg/Trp genotype [odds ratio (OR)=0.88, 95% confidence interval (95% CI): 0.79-0.97], using 4848 cases and 6592 controls from 16 studies. There was no association between lung cancer risk and XRCC1 codon 399 polymorphism in total population, when stratified by source of control, we found a protective effect of the XRCC1 codon 399 Gln/Gln and Arg/Gln or Gln/Gln polymorphisms for lung cancer on the basis of population control (OR=0.73, 95% CI: 0.58-0.92; OR=0.86, 95% CI: 0.77-0.97, respectively). Data indicated that certain XRCC1 codon 399 and 194 variant may affect the susceptibility of lung cancer. Recommendations for further studies include pooling of individual data to facilitate evaluation of multigenic effects and detailed analysis of effect modification by environmental exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1872-7980
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
134-40
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: a meta-analysis.
pubmed:affiliation
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Meta-Analysis