|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0018418,
umls-concept:C0039286,
umls-concept:C0086960,
umls-concept:C0205263,
umls-concept:C0205390,
umls-concept:C0285590,
umls-concept:C0376358,
umls-concept:C1292733,
umls-concept:C1516213,
umls-concept:C1554217
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-2-1
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|
pubmed:abstractText |
Bicalutamide monotherapy is a valuable option for prostate cancer (PCa) patients who wish to avoid the consequences of androgen deprivation; however, this treatment induces gynaecomastia and mastalgia in most patients. Tamoxifen is safe and effective in preventing breast events induced by bicalutamide monotherapy without affecting antitumor activity, but possible interference between bicalutamide and tamoxifen remains a matter of concern. To reduce the exposure to tamoxifen, we considered the putative advantages of weekly administration.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1873-7560
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|
pubmed:author |
pubmed-author:AragonaFrancescoF,
pubmed-author:BedognettiDavideD,
pubmed-author:BoccardoFrancescoF,
pubmed-author:CancliniLucaL,
pubmed-author:ContiGiarioG,
pubmed-author:CortelliniPietroP,
pubmed-author:De CobelliOttavioO,
pubmed-author:Di TonnoPasqualeP,
pubmed-author:GallucciMicheleM,
pubmed-author:LapiniAlbertoA,
pubmed-author:MartoranaGiuseppeG,
pubmed-author:RubagottiAlessandraA,
pubmed-author:UsIuIu
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pubmed:copyrightInfo |
Copyright 2009 European Association of Urology. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
|
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pubmed:volume |
57
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
238-45
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|
pubmed:meshHeading |
pubmed-meshheading:19481335-Aged,
pubmed-meshheading:19481335-Anilides,
pubmed-meshheading:19481335-Antineoplastic Agents,
pubmed-meshheading:19481335-Drug Administration Schedule,
pubmed-meshheading:19481335-Estrogen Antagonists,
pubmed-meshheading:19481335-Gynecomastia,
pubmed-meshheading:19481335-Humans,
pubmed-meshheading:19481335-Male,
pubmed-meshheading:19481335-Middle Aged,
pubmed-meshheading:19481335-Nitriles,
pubmed-meshheading:19481335-Prostatic Neoplasms,
pubmed-meshheading:19481335-Tamoxifen,
pubmed-meshheading:19481335-Tosyl Compounds
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pubmed:year |
2010
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|
pubmed:articleTitle |
An open, randomised, multicentre, phase 3 trial comparing the efficacy of two tamoxifen schedules in preventing gynaecomastia induced by bicalutamide monotherapy in prostate cancer patients.
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|
pubmed:affiliation |
University of Genoa, Genoa, Italy.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
|
