Linked Life Data

19481156

Source:http://linkedlifedata.com/resource/pubmed/id/19481156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-7-31
pubmed:abstractText
Neuroanatomical endophenotypes may reveal insights into the processes by which genetic factors increase the risk of developing schizophrenia. To determine whether patterns of neuroanatomical asymmetries may be useful as schizophrenia-related endophenotypes, we compared patterns of structural asymmetries in patients with schizophrenia, healthy controls, and their respective siblings. The surfaces of the left and right amygdala, hippocampus, thalamus, caudate nucleus, putamen, globus pallidus, and nucleus accumbens were assessed in 40 pairs of healthy comparison controls (CON) and their siblings (CON-SIB) and 25 pairs of patients with schizophrenia (SCZ) and their siblings (SCZ-SIB) in magnetic resonance (MR) images using large deformation diffeomorphic metric mapping (LDDMM) and parallel transport techniques. The within-subject asymmetry deformation of each structure was first measured via LDDMM, and then translated to a global template via parallel transport for evaluation of the patterns of asymmetry both within and across siblings. Our results revealed that asymmetries observed in CON subjects occurred in the amygdala and the anterior segment of the hippocampus with more pronounced expansion deformation in the right-sided structures (R>L asymmetry) but not in the basal ganglia and thalamus. Disturbance in this pattern of asymmetries was observed in both SCZ and SCZ-SIB subjects. More specifically, exaggerations and reductions in the normative pattern of asymmetries were observed in the amygdala-hippocampus formation, basal ganglia, and thalamus. These altered patterns of asymmetries are present in subjects with schizophrenia and their siblings, and therefore may represent a schizophrenia-related endophenotype.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1095-9572
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1221-9
pubmed:dateRevised
2011-5-4
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Neuroanatomical asymmetry patterns in individuals with schizophrenia and their non-psychotic siblings.
pubmed:affiliation
Division of Bioengineering, National University of Singapore, Singapore. bieqa@nus.edu.sg
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural