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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-12-4
|
| pubmed:abstractText |
Five hundred seventy lupus erythematosus patients observed in a private practice between 1980 and 1989 were surveyed. Fifty-five percent were diagnosed after 1980. Five hundred three fulfilled criteria for systemic lupus erythematosus ( [SLE]; 464 idiopathic, 23 overlap, 16 drug-induced) and 67 had biopsy-documented cutaneous (discoid) lupus. In the idiopathic SLE group, symptoms began at a mean age of 31 years and patients were observed for a mean of 6 years. Findings in idiopathic SLE patients were (1) 27% have a family history of autoimmune disease; (2) nephritis patients without nephrotic syndrome rarely develop renal failure (4%); (3) nephrotic syndrome patients are relatively cyclophosphamide-resistant; (4) organ-threatening disease is present in 54%; and (5) 13% of women who become pregnant are recurrent aborters and 26% never conceive. In an analysis of cohort data, 5- and 10-year survivals were 97% +/- 2% and 93% +/- 3%, respectively. Additionally, men and patients with renal disease or thrombocytopenia had a poorer prognosis. Blacks had similar clinical findings and survival to whites. Approximately 50% of deaths were from active disease and 50% from complications of therapy. Prolonged survival has resulted from new diagnostic procedures and serologic tests, and improved antibiotics and antihypertensive agents, as well as more efficacious treatment modalities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0049-0172
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
55-64
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1948102-Adolescent,
pubmed-meshheading:1948102-Adult,
pubmed-meshheading:1948102-Age Factors,
pubmed-meshheading:1948102-Autoimmune Diseases,
pubmed-meshheading:1948102-Child,
pubmed-meshheading:1948102-Child, Preschool,
pubmed-meshheading:1948102-Cohort Studies,
pubmed-meshheading:1948102-Continental Population Groups,
pubmed-meshheading:1948102-Female,
pubmed-meshheading:1948102-Humans,
pubmed-meshheading:1948102-Infant,
pubmed-meshheading:1948102-Infant, Newborn,
pubmed-meshheading:1948102-Lupus Erythematosus, Systemic,
pubmed-meshheading:1948102-Male,
pubmed-meshheading:1948102-Middle Aged,
pubmed-meshheading:1948102-Pregnancy,
pubmed-meshheading:1948102-Pregnancy Complications,
pubmed-meshheading:1948102-Sex Factors,
pubmed-meshheading:1948102-Survival Analysis
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Lupus erythematosus in the 1980s: a survey of 570 patients.
|
| pubmed:affiliation |
Department of Medicine/Division of Rheumatology, Cedars-Sinai Medical Center/UCLA School of Medicine.
|
| pubmed:publicationType |
Journal Article
|