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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-6-16
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pubmed:abstractText |
Autoimmune regulator (Aire) promotes the ectopic expression of tissue-restricted antigens in medullary thymic epithelial cells (mTECs), leading to negative selection of autoreactive T cells. This study was undertaken to determine whether loss of central tolerance renders Aire-deficient (Aire-/-) mice more susceptible to the induction of autoimmune arthritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1683-93
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pubmed:meshHeading |
pubmed-meshheading:19479827-Animals,
pubmed-meshheading:19479827-Arthritis, Experimental,
pubmed-meshheading:19479827-Autoantibodies,
pubmed-meshheading:19479827-Autoimmune Diseases,
pubmed-meshheading:19479827-Autoimmunity,
pubmed-meshheading:19479827-B-Lymphocytes,
pubmed-meshheading:19479827-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19479827-Collagen Type II,
pubmed-meshheading:19479827-Disease Models, Animal,
pubmed-meshheading:19479827-Immunoglobulin G,
pubmed-meshheading:19479827-Mice,
pubmed-meshheading:19479827-Mice, Inbred C57BL,
pubmed-meshheading:19479827-Mice, Knockout,
pubmed-meshheading:19479827-Risk Factors,
pubmed-meshheading:19479827-Severity of Illness Index,
pubmed-meshheading:19479827-Thymus Gland,
pubmed-meshheading:19479827-Transcription Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis.
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pubmed:affiliation |
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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