Source:http://linkedlifedata.com/resource/pubmed/id/19478819
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2009-7-27
|
| pubmed:abstractText |
To identify a gene(s) susceptible to nasopharyngeal carcinoma (NPC), we carried out a genome-wide association study (GWAS) through genotyping of more than 500,000 tag single-nucleotide polymorphisms (SNPs), using an initial sample set of 111 unrelated NPC patients and 260 controls of a Malaysian Chinese population. We further evaluated the top 200 SNPs showing the smallest P-values, using a replication sample set that consisted of 168 cases and 252 controls. The combined analysis of the two sets of samples found an SNP in intron 3 of the ITGA9 (integrin-alpha 9) gene, rs2212020, to be strongly associated with NPC (P=8.27 x 10(-7), odds ratio (OR)=2.24, 95% confidence intervals (CI)=1.59-3.15). The gene is located at 3p21 which is commonly deleted in NPC cells. We subsequently genotyped additional 19 tag SNPs within a 40-kb linkage disequilibrium (LD) block surrounding this landmark SNP. Among them, SNP rs189897 showed the strongest association with a P-value of 6.85 x 10(-8) (OR=3.18, 95% CI=1.94-5.21), suggesting that a genetic variation(s) in ITGA9 may influence susceptibility to NPC in the Malaysian Chinese population.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1435-232X
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| pubmed:author |
pubmed-author:GovindarajuSelvaratnamS,
pubmed-author:KamataniNaoyukiN,
pubmed-author:KrishnanGopalaG,
pubmed-author:KuboMichiakiM,
pubmed-author:LimPaul Vey HongPV,
pubmed-author:MushirodaTaiseiT,
pubmed-author:NakamuraYusukeY,
pubmed-author:NgChing ChingCC,
pubmed-author:PuahSuat MoiSM,
pubmed-author:RatnaveluKananathanK,
pubmed-author:SamChoon KookCK,
pubmed-author:TakahashiAtsushiA,
pubmed-author:TeoSoo HwangSH,
pubmed-author:YapLee FahLF,
pubmed-author:YewPoh YinPY
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
392-7
|
| pubmed:meshHeading |
pubmed-meshheading:19478819-Adolescent,
pubmed-meshheading:19478819-Adult,
pubmed-meshheading:19478819-Aged,
pubmed-meshheading:19478819-Alleles,
pubmed-meshheading:19478819-Asian Continental Ancestry Group,
pubmed-meshheading:19478819-Case-Control Studies,
pubmed-meshheading:19478819-Female,
pubmed-meshheading:19478819-Genetic Predisposition to Disease,
pubmed-meshheading:19478819-Genome-Wide Association Study,
pubmed-meshheading:19478819-Humans,
pubmed-meshheading:19478819-Integrins,
pubmed-meshheading:19478819-Linkage Disequilibrium,
pubmed-meshheading:19478819-Malaysia,
pubmed-meshheading:19478819-Male,
pubmed-meshheading:19478819-Middle Aged,
pubmed-meshheading:19478819-Nasopharyngeal Neoplasms,
pubmed-meshheading:19478819-Polymorphism, Single Nucleotide,
pubmed-meshheading:19478819-Reproducibility of Results,
pubmed-meshheading:19478819-Young Adult
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.
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| pubmed:affiliation |
Laboratory for International Alliance, RIKEN Center for Genomic Medicine, Tsurumi-ku, Yokohama, Japan. ccng@um.edu.my
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|